Lin Kuo-Wei, Tsai Chi-Hui, Hsieh I-Lin, Yan Tu-Hsin
Department of Chemistry, National Chung-Hsing University, Taichung 400, Taiwan, Republic of China.
Org Lett. 2008 May 15;10(10):1927-30. doi: 10.1021/ol8004326. Epub 2008 Apr 12.
The direct coupling of a variety of amides with CH2 Cl2 or CD2 Cl2 promoted by TiCl 4/Mg/THF provides an extremely simple, practical, selective, and efficient approach for the construction of methyl ketones. The efficiency and practicability of this chemistry is illustrated by the very simple synthesis of deuterated methyl ketones.
在四氯化钛/镁/四氢呋喃的促进下，各种酰胺与二氯甲烷或二氯氘甲烷的直接偶联为甲基酮的构建提供了一种极其简单、实用、选择性高且高效的方法。氘代甲基酮的非常简单的合成说明了这种化学方法的效率和实用性。
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