抗体-细胞因子融合蛋白：在癌症治疗中的应用
Antibody-cytokine fusion proteins: applications in cancer therapy.
作者信息
Ortiz-Sánchez Elizabeth, Helguera Gustavo, Daniels Tracy R, Penichet Manuel L
机构信息
University of California, Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine, Los Angeles, CA 90095, USA.
出版信息
Expert Opin Biol Ther. 2008 May;8(5):609-32. doi: 10.1517/14712598.8.5.609.
Abstract
BACKGROUND
Antibody-cytokine fusion proteins consist of cytokines fused to an antibody to improve antibody-targeted cancer immunotherapy. These molecules have the capacity to enhance the tumoricidal activity of the antibodies and/or activate a secondary antitumor immune response.
OBJECTIVE
To review the strategies used to develop antibody-cytokine fusion proteins and their in vitro and in vivo properties, including preclinical and clinical studies focusing on IL-2, IL-12 and GM-CSF.
METHODS
Articles were found by searching databases such as PubMed and Clinical Trials of the US National Institutes of Health.
RESULTS/CONCLUSION: Multiple antibody-cytokine fusion proteins have demonstrated significant antitumor activity as direct therapeutics or as adjuvants of cancer vaccines in preclinical studies, paving the way for their clinical evaluation.
摘要
背景
抗体 - 细胞因子融合蛋白由与抗体融合的细胞因子组成，用于改善抗体靶向的癌症免疫治疗。这些分子能够增强抗体的杀肿瘤活性和/或激活继发性抗肿瘤免疫反应。
目的
综述用于开发抗体 - 细胞因子融合蛋白的策略及其体外和体内特性，包括聚焦于白细胞介素 - 2、白细胞介素 - 12和粒细胞巨噬细胞集落刺激因子的临床前和临床研究。
方法
通过检索诸如美国国立医学图书馆的PubMed数据库和美国国立卫生研究院的临床试验等数据库来查找文章。
结果/结论：多种抗体 - 细胞因子融合蛋白在临床前研究中已证明作为直接治疗剂或癌症疫苗佐剂具有显著的抗肿瘤活性，为其临床评估铺平了道路。
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