Scharschmidt Tiffany C, Segre Julia A
University of California, San Francisco School of Medicine, San Francisco, California, USA.
J Invest Dermatol. 2008 May;128(5):1061-4. doi: 10.1038/sj.jid.5701201.
Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder that affects approximately 15% of children in the United States. A complex disorder, AD is characterized by both skin barrier impairment and immunologic abnormalities, including decreased innate immune function and a polarized adaptive immune response. Mouse models have demonstrated the complex interdependence of immune cell-keratinocyte interactions and teased apart gene-environment relationships in a controlled setting. In this issue, Nagelkerken et al. present a mouse model with transgenic expression of apolipoprotein C1 that disrupts the skin lipid barrier and manifests many hallmark features of AD.
特应性皮炎（AD）是一种慢性复发性炎症性皮肤病，在美国约15%的儿童中受其影响。AD是一种复杂的疾病，其特征在于皮肤屏障受损和免疫异常，包括先天性免疫功能降低和适应性免疫反应极化。小鼠模型已经证明了免疫细胞与角质形成细胞相互作用之间复杂的相互依存关系，并在可控环境中梳理出基因与环境的关系。在本期中，纳格尔肯等人展示了一种载脂蛋白C1转基因表达的小鼠模型，该模型破坏了皮肤脂质屏障，并表现出AD的许多标志性特征。
