Levin Jacquelyn, Fallon Friedlander Sheila, Del Rosso James Q
Dr. Levin is from Largo Medical Center, Largo, Florida. Dr. Friedlander is from University Of California San Diego, San Diego, California. Dr. Del Rosso is from Valley Hospital Medical Center, Las Vegas, Nevada.
J Clin Aesthet Dermatol. 2013 Dec;6(12):37-44.
Part 3 of this three-part review of atopic dermatitis and the stratum corneum barrier discerns how immune dysregulation, including upregulation of a TH2 inflammation pattern, augmented allergic sensitization, sustained wound healing inflammation, and impaired innate immunity, plays an integral role in the pathogenesis of atopic dermatitis. An increased understanding of the interdependence, polymorphisms, and dysregulations of epidermal barrier functions, including the stratum corneum permeability barrier, immune defense, and antimicrobial barriers, should provide further knowledge about the pathophysiological mechanisms that are clinically relevant and that contribute to the development of atopic dermatitis. Further understanding of these mechanisms should lead to newer therapies that target specific pathogenic components of atopic dermatitis.
这篇关于特应性皮炎和角质层屏障的三部分综述的第三部分，探讨了免疫失调在特应性皮炎发病机制中所起的重要作用，包括TH2炎症模式上调、过敏致敏增强、伤口愈合炎症持续以及先天免疫受损。对表皮屏障功能（包括角质层渗透屏障、免疫防御和抗菌屏障）的相互依存关系、多态性和失调的深入理解，应能为与临床相关且导致特应性皮炎发展的病理生理机制提供更多知识。对这些机制的进一步理解应能催生针对特应性皮炎特定致病成分的新疗法。
