[曼弗雷多尼亚地区一家废弃工厂中接触无机砷工人的生物监测]

[Biological monitoring in workers exposed to inorganic arsenic in a disused industrial plant in the area of Manfredonia].

作者信息

Vimercati L, Carrus A, Gagliardi T, Sciannamblo G, Caputo F, Minunni V, Bellotta M R, de Nichilo G, Bisceglia L, Corrado V, De Pasquale P, Assennato G

机构信息

Dipartimento di Medicina Interna e Medicina Pubblica, Sezione di Medicina del Lavoro B. Ramazzini, Facoltà di Medicina e Chirurgia, Università degli Studi di Bari, Policlinico, Piazza G. Cesare 11, 70124 Bari.

出版信息

G Ital Med Lav Ergon. 2007 Jul-Sep;29(3 Suppl):268-9.

PMID:18409679

Abstract

Inorganic arsenic and its methylated metabolities were measured in 108 spot urine samples obtained from the medical surveillance programme of workers exposed to inorganic Arsenic in July 2006. 15% of the samples showed levels higher than limit value of 35 microg/L (mean value 23,9 microg/L). After the improvement of the working conditions, in August-October 2006, we collected a urinary sample from each of the 108 workers enrolled. A questionnaire was also administrated, in order to investigate the influence of occupational and non occupational factors on the urinary arsenic excretion. The median value of urinary arsenic was 15,12 microg/L; among the 108 samples, 5% showed levels higher than limit value. A significant difference was observed in relation with sea-food consumption and aging stratification. In conclusion, we have described a significant reduction of urinary arsenic excretion between the two phases of biological monitoring, likely due to a proper hygienic work-related intervention.

摘要

2006年7月，对从无机砷暴露工人医学监测项目中采集的108份随机尿样进行了无机砷及其甲基化代谢物的检测。15%的样本显示水平高于35微克/升的限值（平均值为23.9微克/升）。在改善工作条件后，于2006年8月至10月，我们从108名登记工人中每人采集了一份尿样。还发放了一份问卷，以调查职业和非职业因素对尿砷排泄的影响。尿砷的中位数为15.12微克/升；在108份样本中，5%的样本显示水平高于限值。在与海鲜消费和年龄分层方面观察到显著差异。总之，我们描述了两个生物监测阶段之间尿砷排泄的显著减少，这可能归因于适当的与工作相关的卫生干预措施。