Stephen Franks is at the Department of Obstetrics and Gynaecology, St. Mary's Hospital Medical School, London W2 1PG, UK.
Trends Endocrinol Metab. 1989 Nov-Dec;1(2):60-3. doi: 10.1016/1043-2760(89)90003-9.
This case illustrates the very common endocrine problem of polycystic ovary syndrome (PCOS). The diagnosis was not clear initially because of the absence of clinical evidence of androgen excess and of a normal random serum luteinizing hormone (LH) concentration. Futher investigations, however, confirmed polycystic ovaries on ultrasound and revealed a raised serum LH and elevated testosterone despite the lack of hirsutism. The patient's anovulatory infertility was treated by low dose human menopausal gonadotrophin (HMG), which resulted in ovulation of a single dominant follicle and pregnancy in the first cycle of treatment. This article discusses the endocrine features of hirsute and nonhirsute patients with PCOS, the choice of treatment for induction of ovulation, and comments on the possible mechanisms underlying PCOS.
本病例说明了多囊卵巢综合征（PCOS）这一非常常见的内分泌问题。最初的诊断并不明确，因为没有雄激素过多的临床证据，且随机血清黄体生成素（LH）浓度正常。然而，进一步的检查在超声检查中证实了多囊卵巢，并显示血清 LH 升高和睾酮升高，尽管没有多毛症。该患者的无排卵性不孕通过小剂量人绝经期促性腺激素（HMG）治疗，导致单个优势卵泡排卵和治疗的第一个周期怀孕。本文讨论了有和无多毛症的 PCOS 患者的内分泌特征、诱导排卵的治疗选择，并对 PCOS 的可能机制进行了评论。
