Sylus Angel Mercy, Nandeesha Hanumanthappa, Chitra Thiagaraju
Department of Biochemistry, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India.
Obstetrics and Gynecology, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India.
Int J Reprod Biomed. 2020 Aug 19;18(8):605-610. doi: 10.18502/ijrm.v13i8.7502. eCollection 2020 Aug.
Obesity, inflammation and alterations in matrix metalloproteinase-9 (MMP-9) and nitric oxide (NO) levels are involved in the development of polycystic ovary syndrome (PCOS).
To investigate the relationship of MMP-9, NO and interleukin-10 (IL-10) with the increase in body mass index (BMI) in women with PCOS.
Sixty two infertile PCOS women were included in the study. Serum levels of NO, IL-10 and MMP-9 were assessed in the women with increase in BMI.
MMP-9 was significantly increased (p = 0.029) and IL-10 (p = 0.015) was significantly reduced in obese PCOS subjects compared to those with lesser BMI. MMP-9 levels positively correlated with the duration of infertility (r = 0.253, p = 0.047) and negatively correlated with NO levels (r = - 0.259, p = 0.042). A significant negative correlation between the interleukin-10 levels and the BMI (r = - 0.272, p = 0.033) was also found in the PCOS subjects.
MMP-9 levels are increased in obese PCOS women and it is associated with NO levels and the duration of infertility.
肥胖、炎症以及基质金属蛋白酶-9（MMP-9）和一氧化氮（NO）水平的改变与多囊卵巢综合征（PCOS）的发生发展有关。
探讨MMP-9、NO和白细胞介素-10（IL-10）与PCOS女性体重指数（BMI）升高之间的关系。
本研究纳入62例不孕的PCOS女性。对BMI升高的女性评估血清NO、IL-10和MMP-9水平。
与BMI较低的PCOS受试者相比，肥胖的PCOS受试者中MMP-9显著升高（p = 0.029），IL-10显著降低（p = 0.015）。MMP-9水平与不孕持续时间呈正相关（r = 0.253，p = 0.047），与NO水平呈负相关（r = - 0.259，p = 0.042）。在PCOS受试者中还发现白细胞介素-10水平与BMI之间存在显著负相关（r = - 0.272，p = 0.033）。
肥胖的PCOS女性中MMP-9水平升高，且与NO水平和不孕持续时间有关。
