Peng Bo, Amos Christopher I
Department of Epidemiology, The University of Texas, M. D. Anderson Cancer Center, 1155 Pressler Blvd, Houston, TX 77030, USA.
Bioinformatics. 2008 Jun 1;24(11):1408-9. doi: 10.1093/bioinformatics/btn179. Epub 2008 Apr 15.
Computer simulations play an important role in studies of non-random mating populations. Because of implementation difficulties, only very limited types of non-random mating schemes are provided in the currently available simulation programs. Starting with version 0.8.5, simuPOP provides a few mating schemes that can be used to simulate arbitrary non-random mating models. This article describes the concepts and methods behind these mating schemes and demonstrates their uses in a few examples, including partial self-mating, positive assortative mating, non-random outbreeding, and simulation of overlapping generations in age-structured populations.
simuPOP is freely available at http://simupop.sourceforge.net, distributed under a GPL license. Cited examples are in the doc/cookbook directory of a simuPOP distribution.
计算机模拟在非随机交配种群的研究中发挥着重要作用。由于实现困难,当前可用的模拟程序仅提供非常有限类型的非随机交配方案。从0.8.5版本开始,simuPOP提供了一些交配方案,可用于模拟任意非随机交配模型。本文介绍了这些交配方案背后的概念和方法,并在一些示例中展示了它们的用途,包括部分自交、正选型交配、非随机远交以及年龄结构种群中重叠世代的模拟。
simuPOP可在http://simupop.sourceforge.net免费获取,根据GPL许可分发。引用的示例位于simuPOP发行版的doc/ cookbook目录中。