Zhou J
Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academe of Sciences, Yunnan.
Mem Inst Oswaldo Cruz. 1991;86 Suppl 2:231-4. doi: 10.1590/s0074-02761991000600051.
Glycosides are the bioactive components of many famous Chinese medicines. Here reported are some bioactive glycosides we discovered from Chinese medicines in recent years. (1) Phenolic glycosides from Chinese medicines: Gastrodia elata, Aconitum austroyunanense and Helicia erratica, three bioactive phenolic glycosides were discovered and two of them have been developed into new drugs. (2) Terpenoidal glycosides: a) Monoterpenoid: the sweroside from Swertia moleensis has been developed into an anti-hepatitis drug; b) Diterpenoid: Phlomis betonicoides contains sweet glycosides; c) Triterpenoid: many biologically active triterpenoid glycosides were isolated from Panax plants and Siraitia grosvenorii. (3) Steroidal glycosides: a) C21-steroid: Cynanchum otophyllum and C. atratrum contain anti-epilepsy and anti-tumor glycosides; b) C27-steroid Hemostatic saponins were found in Paris polyphylla.
糖苷是许多著名中药的生物活性成分。以下是我们近年来从中药中发现的一些生物活性糖苷。(1)中药中的酚苷:天麻、滇南乌头和山龙眼,发现了三种生物活性酚苷,其中两种已开发成新药。(2)萜类糖苷:a)单萜:青叶胆中的獐牙菜苷已开发成抗肝炎药物;b)二萜:糙苏含有甜味糖苷;c)三萜:从人参属植物和罗汉果中分离出许多具有生物活性的三萜糖苷。(3)甾体糖苷:a)C21甾体:耳叶牛皮消和白首乌含有抗癫痫和抗肿瘤糖苷;b)C27甾体:七叶一枝花中发现了止血皂苷。