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中药中的生物活性糖苷。

Bioactive glycosides from Chinese medicines.

作者信息

Zhou J

机构信息

Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academe of Sciences, Yunnan.

出版信息

Mem Inst Oswaldo Cruz. 1991;86 Suppl 2:231-4. doi: 10.1590/s0074-02761991000600051.

Abstract

Glycosides are the bioactive components of many famous Chinese medicines. Here reported are some bioactive glycosides we discovered from Chinese medicines in recent years. (1) Phenolic glycosides from Chinese medicines: Gastrodia elata, Aconitum austroyunanense and Helicia erratica, three bioactive phenolic glycosides were discovered and two of them have been developed into new drugs. (2) Terpenoidal glycosides: a) Monoterpenoid: the sweroside from Swertia moleensis has been developed into an anti-hepatitis drug; b) Diterpenoid: Phlomis betonicoides contains sweet glycosides; c) Triterpenoid: many biologically active triterpenoid glycosides were isolated from Panax plants and Siraitia grosvenorii. (3) Steroidal glycosides: a) C21-steroid: Cynanchum otophyllum and C. atratrum contain anti-epilepsy and anti-tumor glycosides; b) C27-steroid Hemostatic saponins were found in Paris polyphylla.

摘要

糖苷是许多著名中药的生物活性成分。以下是我们近年来从中药中发现的一些生物活性糖苷。(1)中药中的酚苷:天麻、滇南乌头和山龙眼,发现了三种生物活性酚苷,其中两种已开发成新药。(2)萜类糖苷:a)单萜:青叶胆中的獐牙菜苷已开发成抗肝炎药物;b)二萜:糙苏含有甜味糖苷;c)三萜:从人参属植物和罗汉果中分离出许多具有生物活性的三萜糖苷。(3)甾体糖苷:a)C21甾体:耳叶牛皮消和白首乌含有抗癫痫和抗肿瘤糖苷;b)C27甾体:七叶一枝花中发现了止血皂苷。

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