用于医学的聚合物合成的组合方法与合理方法。
Combinatorial and rational approaches to polymer synthesis for medicine.
作者信息
Goldberg Michael, Mahon Kerry, Anderson Daniel
机构信息
Harvard, MIT Division of Health Sciences and Technology, USA.
出版信息
Adv Drug Deliv Rev. 2008 Jun 10;60(9):971-8. doi: 10.1016/j.addr.2008.02.005. Epub 2008 Mar 4.
Abstract
High-throughput, combinatorial methods have revolutionized small molecule synthesis and drug discovery. By combining automation, miniaturization, and parallel synthesis techniques, large collections of new compounds have been synthesized and screened. It is becoming increasingly clear that these same approaches can also assist the discovery and development of novel biomaterials for medicine. This review examines combinatorial and rational polymer synthesis for medical applications, including stem cell engineering and nucleic acid drug delivery.
摘要
高通量组合方法彻底改变了小分子合成和药物发现。通过结合自动化、小型化和平行合成技术，已经合成并筛选了大量新化合物。越来越明显的是，这些相同的方法也可以辅助用于医学的新型生物材料的发现和开发。本文综述了用于医学应用的组合和理性聚合物合成，包括干细胞工程和核酸药物递送。
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