Sidwell Rachel U, Francis Nick D, Basarab Tamara, Morar Nilesh
Department of Dermatology, Chelsea and Westminster Hospital, London, United Kingdom.
Pediatr Dermatol. 2008 Mar-Apr;25(2):201-4. doi: 10.1111/j.1525-1470.2008.00634.x.
Allergic contact dermatitis reaction to topical "black henna" tattoo is usually described secondary to the organic dye para-phenylenediamine, a derivative of analine. Allergic contact dermatitis reactions to para-phenylenediamine are well recognized and most commonly involve an eczematous reaction that may become generalized and an acute angio-edema. Only four previous instances have been reported of an erythema multiforme-like reaction to para-phenylenediamine and its derivatives, including only one mild reaction to a tattoo. A vesicular erythema multiforme-like reaction has not been reported. An erythema multiforme-like reaction to contact allergens is usually caused by potent allergens including plant quinolones in Compositae and sesquiterpene lactones in exotic woods, and it is also reported to topical drugs, epoxy resin, metals (particularly nickel), and various chemicals. A generalized vesicular erythema multiforme-like reaction is unusual, and rarely reported. We describe a 6-year-old boy who developed a localized, eczematous and severe generalized vesicular erythema multiforme-like contact allergy to para-phenylenediamine secondary to a henna tattoo. As henna tattoos are becoming increasingly popular, one should be aware of the possibility of such a reaction. This presentation also highlights the call to ban the use of para-phenylenediamine and its derivatives in dyes.
对局部“黑色指甲花”纹身的过敏性接触性皮炎反应通常被描述为继发于有机染料对苯二胺，它是苯胺的衍生物。对苯二胺的过敏性接触性皮炎反应已得到充分认识，最常见的是涉及可能泛发的湿疹样反应和急性血管性水肿。此前仅报道过4例对苯二胺及其衍生物的多形红斑样反应，其中仅有1例是对纹身的轻度反应。尚未报道过水疱性多形红斑样反应。对接触性变应原的多形红斑样反应通常由强效变应原引起，包括菊科植物中的植物喹诺酮和外来木材中的倍半萜内酯，也有报道称其与局部用药、环氧树脂、金属（尤其是镍）和各种化学物质有关。全身性水疱性多形红斑样反应并不常见，报道很少。我们描述了一名6岁男孩，他因指甲花纹身继发对苯二胺出现局限性、湿疹样且严重的全身性水疱性多形红斑样接触性过敏。由于指甲花纹身越来越受欢迎，人们应该意识到这种反应的可能性。本病例报告还强调了呼吁禁止在染料中使用对苯二胺及其衍生物。
