Nikiforova I F, Pluzhnikova G F, Serova O M, Kniazev P G
Vopr Onkol. 1991;37(6):700-5.
Size and frequency of rare alleles of HRAS1 protooncogene were studied in 258 patients with various neoplasms and 32 healthy donors of the northwestern region of the USSR. Literature data on distribution of rare alleles of certain size in sick and healthy people were compared to our results. On the whole, 1918 HRAS1 alleles from cancer patients and 1104 alleles from donors were considered. The study established a significant increase in the frequency of rare A6 allele in cancer patients.
对苏联西北地区的258例各种肿瘤患者和32名健康献血者的HRAS1原癌基因稀有等位基因的大小和频率进行了研究。将有关患病和健康人群中特定大小稀有等位基因分布的文献数据与我们的研究结果进行了比较。总体而言，共分析了1918个癌症患者的HRAS1等位基因和1104个献血者的等位基因。该研究证实癌症患者中稀有A6等位基因的频率显著增加。
