Kulmala Jenni, Era Pertti, Törmäkangas Timo, Pärssinen Olavi, Rantanen Taina, Heikkinen Eino
Department of Health Sciences, University of Jyväskylä, Jyvaskyla, Finland.
Ophthalmic Epidemiol. 2008 Mar-Apr;15(2):128-34. doi: 10.1080/09286580701840388.
To examine vision as a predictor of mortality in older people and the role of mobility, depressed mood, chronic diseases, body mass index, physical activity and injurious accidents in this possible association.
223 persons aged 75 and 193 persons aged 80 years at the baseline participated in visual acuity measurements. Visual acuity (VA) of < 0.3 in the better eye was defined as visual impairment, VA of > or = 0.3 but < or = 0.5 as lowered vision and VA > 0.5 as normal VA. Death dates were received from the official register. Cox regression models were used to determine the relative risks of mortality and to study what factors lie on the pathway from poor vision to mortality.
Over the 10-year follow-up, 107 (48%) persons aged 75 years and 138 (72%) aged 80 years at the baseline died. The risk for mortality among the 75-year-olds with lowered vision was 1.98 (95 % CI 1.25-3.13) and with visual impairment 1.90 (95% CI 1.12-3.20) compared to those with normal VA. Lower walking speed, physical inactivity, cardiovascular diseases, injurious accidents, diabetes and depressed mood each attenuated the risk markedly. Nevertheless, lowered vision remained a significant predictor of mortality even after including all these variables in the model. Among the 80-year-olds vision did not correlate with mortality.
Lowered vision and severe visual impairment predicted mortality in the 75-year-old but not 80-year-old population. The increased risk was partially explained by lower walking speed, physical inactivity, cardiovascular diseases, depressed mood, diabetes and injurious accidents.
研究视力作为老年人死亡率预测指标的情况,以及行动能力、情绪低落、慢性病、体重指数、身体活动和意外伤害在这种可能关联中所起的作用。
223名75岁及193名80岁的基线参与者接受了视力测量。较好眼视力<0.3被定义为视力损害,视力≥0.3但≤0.5为视力下降,视力>0.5为正常视力。从官方登记处获取死亡日期。使用Cox回归模型确定死亡的相对风险,并研究从视力差到死亡的途径上有哪些因素。
在10年的随访中,基线时223名75岁的参与者中有107人(48%)死亡,193名80岁的参与者中有138人(72%)死亡。与视力正常的75岁老人相比,视力下降的老人死亡风险为1.98(95%可信区间1.25 - 3.13),视力损害的老人死亡风险为1.90(95%可信区间1.12 - 3.20)。步行速度较慢、缺乏身体活动、患有心血管疾病、发生意外伤害、患有糖尿病和情绪低落均显著降低了风险。然而,即使在模型中纳入所有这些变量后,视力下降仍然是死亡的显著预测指标。在80岁的人群中,视力与死亡率无关。
视力下降和严重视力损害可预测75岁人群的死亡率,但不能预测80岁人群的死亡率。步行速度较慢、缺乏身体活动、患有心血管疾病、情绪低落、患有糖尿病和发生意外伤害部分解释了死亡风险的增加。