Friemann J, Müller K M, Pott F
Institut für Pathologie, Universitätsklinik, Bochum, FRG.
Pathol Res Pract. 1990 Feb;186(1):117-23. doi: 10.1016/S0344-0338(11)81019-8.
The intraperitoneal test in rats has proven to be an appropriate method controlling fibrogenicity and carcinogenicity of asbestos fibres and other fibrous dusts. We analyzed the reaction patterns of mesothelial cover layer to different natural mineral fibres (crocidolite, chrysotile, actinolite, erionite, wollastonite) and man-made mineral and synthetic fibres (glass fibres 104/475, polypropylene, aramide fibres). The injection of doses between 0.01 and 100 mg dust suspended in saline solution led to a continued repairing proliferation of submesothelial connective tissue cells and focal submesothelial fibrosis. These changes were never observed after application of granular dusts as mine dust and quartz. After 15 to 28 months we often found an association of fibrosis and local reactive hyperplasia of partly atypical proliferation of rat omentum mesothelium. These changes were also demonstrated in cases without macroscopically visible tumors. In later stages the underlying fibrosis was often infiltrated and dissolved by mesotheliomas.
大鼠腹腔内试验已被证明是一种控制石棉纤维及其他纤维性粉尘致纤维化性和致癌性的合适方法。我们分析了间皮覆盖层对不同天然矿物纤维（青石棉、温石棉、阳起石、毛沸石、硅灰石）以及人造矿物纤维和合成纤维（玻璃纤维104/475、聚丙烯、芳纶纤维）的反应模式。注射悬浮于盐溶液中的0.01至100毫克粉尘剂量会导致间皮下结缔组织细胞持续的修复性增殖以及局灶性间皮下纤维化。应用粒状粉尘（如矿尘和石英）后从未观察到这些变化。15至28个月后，我们经常发现大鼠大网膜间皮部分非典型增生的纤维化与局部反应性增生相关联。在无肉眼可见肿瘤的病例中也证实了这些变化。在后期，潜在的纤维化常被间皮瘤浸润并溶解。
