0.4% 酮咯酸氨丁三醇用于治疗过敏性结膜炎。
Ketorolac tromethamine 0.4% as a treatment for allergic conjuctivitis.
作者信息
Schechter Barry A
机构信息
Florida Eye Microsurgical Institute, 1717 W Woolbright Road, Boynton Beach, FL 33426, USA.
出版信息
Expert Opin Drug Metab Toxicol. 2008 Apr;4(4):507-11. doi: 10.1517/17425255.4.4.507.
BACKGROUND
Acular LS (ketorolac tromethamine 0.4%) ophthalmic solution, a reformulation of the original Acular (ketorolac tromethamine 0.5%), is indicated for the reduction of ocular pain and burning/stinging following corneal refractive surgery.
OBJECTIVE
This manuscript will review the off-label application of this topical NSAID medication as a treatment for allergic conjunctivitis.
METHODS
An extensive MedLine search was undertaken to evaluate data on the use of ketorolac for allergic conjunctivitis. Data on both human and animal data were reviewed.
RESULTS/CONCLUSIONS: Studies have demonstrated that ketorolac 0.4% has equivalent efficacy to ketorolac 0.5%. Several studies have demonstrated that ketorolac effectively treats allergic conjunctivitis. Ketorolac 0.4% is effective when used as either monotherapy or as adjunct therapy to steroids.
背景
Acular LS（0.4% 酮咯酸氨丁三醇）眼药水是原 Acular（0.5% 酮咯酸氨丁三醇）的重新配方，适用于减轻角膜屈光手术后的眼部疼痛和灼烧/刺痛感。
目的
本文将综述这种局部非甾体抗炎药作为过敏性结膜炎治疗方法的超说明书应用。
方法
进行了广泛的医学文献数据库检索，以评估使用酮咯酸治疗过敏性结膜炎的数据。对人类和动物数据均进行了综述。
结果/结论：研究表明，0.4% 酮咯酸与 0.5% 酮咯酸具有同等疗效。多项研究表明，酮咯酸能有效治疗过敏性结膜炎。0.4% 酮咯酸作为单一疗法或作为类固醇的辅助疗法均有效。
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