Sitenga G L, Ing E B, Van Dellen R G, Younge B R, Leavitt J A
Department of Ophthalmology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA.
Ophthalmology. 1996 Jun;103(6):890-2. doi: 10.1016/s0161-6420(96)30591-5.
Ketorolac tromethamine 0.5 percent ophthalmic solution is a widely used nonsteroidal anti-inflammatory drug (NSAID) in ophthalmology. Ketorolac eye drops have not been implicated previously as a cause of NSAID-induced asthma.
A patient with severe asthma after topical application of ketorolac is described. The current ophthalmic indications for topical application of ketorolac and reported hypersensitivity reactions with systemic use of ketorolac are reviewed.
A 44-year-old woman with chronic asthma, rhinosinusitis, and nasal polyps inadvertently was given ketorolac to be applied topically. After applying the first dose of ketorolac, an exacerbation of her asthma developed, necessitating hospital admission.
Topical application of ketorolac is safe in the vast majority of ophthalmology patients. However, NSAID eye drops should not be prescribed for patients with aspirin or NSAID allergy or the combination of asthma and nasal polyps unless the patient is known to tolerate aspirin without trouble.
0.5%的酮咯酸氨丁三醇眼药水是眼科广泛使用的非甾体抗炎药（NSAID）。此前，酮咯酸眼药水尚未被认为是NSAID诱发哮喘的病因。
本文描述了一名局部应用酮咯酸后出现严重哮喘的患者。回顾了目前酮咯酸局部应用的眼科适应证以及全身应用酮咯酸时报告的过敏反应。
一名患有慢性哮喘、鼻窦炎和鼻息肉的44岁女性无意中被给予酮咯酸局部应用。在应用第一剂酮咯酸后，她的哮喘病情加重，需要住院治疗。
在绝大多数眼科患者中，局部应用酮咯酸是安全的。然而，除非已知患者能耐受阿司匹林且无不良反应，否则不应为阿司匹林或NSAID过敏或患有哮喘合并鼻息肉的患者开具NSAID眼药水。
