播散性睾丸癌男性的精液质量：与人类绒毛膜促性腺激素β亚基及垂体性腺激素的关系。

Semen quality in men with disseminated testicular cancer: relation with human chorionic gonadotropin beta-subunit and pituitary gonadal hormones.

作者信息

de Bruin Daphne, de Jong Igle J, Arts Eugène G J M, Nuver Janine, Dullaart Robin P F, Sluiter Willem J, Hoekstra Harald J, Sleijfer Dirk T, Gietema Jourik A

机构信息

Department of Urology, University of Groningen, University Medical Center, Groningen, The Netherlands.

出版信息

Fertil Steril. 2009 Jun;91(6):2481-6. doi: 10.1016/j.fertnstert.2008.03.016. Epub 2008 Apr 28.

DOI:10.1016/j.fertnstert.2008.03.016

PMID:18440530

Abstract

OBJECTIVE

To compare the semen quality and hormonal status between patients with testicular cancer and normal versus increased serum levels of beta-hCG.

DESIGN

Retrospective study.

SETTING

Academic research environment.

PATIENT(S): All 203 patients with testicular cancer who required chemotherapy in the period 1995-2003 were included.

INTERVENTION(S): In 107 patients semen samples were stored by cryopreservation; 62 patients could be analyzed because both semen was stored and hormones were determined before starting chemotherapy (median age 25 years, range 17-49 years).

MAIN OUTCOME MEASURE(S): Total motile sperm count, T, E(2), LH, FSH, and PRL.

RESULT(S): Total motile sperm count was decreased in patients with increased beta-hCG (median 11.9 x 10(6)) compared with patients with normal beta-hCG (median 21.5 x 10(6)). Testosterone, E(2), and PRL were significantly higher in patients with increased beta-hCG levels, whereas LH and FSH were lower. Semen quality was significantly and negatively correlated with beta-hCG, E(2), and PRL.

CONCLUSION(S): Patients with increased beta-hCG had an inferior spermatogenesis compared with patients with normal beta-hCG. Increased beta-hCG appears to be associated with impaired spermatogenesis and increased levels of E(2) and PRL.

摘要