Lindqvist Olav, Rasmussen Birgit H, Widmark Anders
Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.
Eur J Oncol Nurs. 2008 Sep;12(4):283-90. doi: 10.1016/j.ejon.2008.03.003. Epub 2008 Apr 28.
Advanced prostate cancer with skeletal metastases entails significant symptoms from both treatment and the disease itself. Although the diagnosis is a common one, knowledge of the symptom experience late in the disease trajectory is limited. The aim of the present study was to describe the experience of physical symptoms in men with hormone refractory prostate cancer and skeletal metastases. Twenty men answered a quality of life questionnaire before participating in semi-structured interviews. The interviews were analyzed using qualitative description. Findings show that the dominant symptoms were lack of energy and pain. Interestingly when talking about lacking energy the men described three different variants; lack of mental energy or initiative, lack of strength and stamina, and tiredness or sleepiness. Also, three different types of pain were described; pain from skeletal metastases, a diffuse moving pain, and pain not directly caused by the prostate cancer. Though a majority of the men scored being dissatisfied with their sex life; in the interviews, this was not described as a major distress. The findings also showed that the men experienced different symptoms despite the same diagnosis, skeletal metastases, stage, and androgen deprivation treatment, and that these symptoms are not necessarily experienced as problems or causing distress.
伴有骨转移的晚期前列腺癌会因治疗和疾病本身而引发严重症状。尽管这一诊断很常见，但对于疾病进展后期症状体验的了解却很有限。本研究的目的是描述激素难治性前列腺癌和骨转移男性患者的身体症状体验。20名男性在参加半结构化访谈前回答了一份生活质量问卷。访谈采用定性描述法进行分析。研究结果表明，主要症状是精力不足和疼痛。有趣的是，在谈到精力不足时，男性描述了三种不同的情况：缺乏精神活力或主动性、缺乏力量和耐力、疲倦或困倦。此外，还描述了三种不同类型的疼痛：骨转移引起的疼痛、弥漫性游走性疼痛以及并非由前列腺癌直接导致的疼痛。尽管大多数男性对自己的性生活不满意，但在访谈中，这并未被描述为主要困扰。研究结果还表明，尽管诊断相同、均有骨转移、处于相同阶段且接受雄激素剥夺治疗，但这些男性仍经历了不同的症状，而且这些症状不一定被视为问题或造成困扰。
