血清γ-谷氨酰转移酶与正常血压的中国成年人尿酸水平升高有关。

Serum gamma-glutamyl transferase is associated with the elevated uric acid levels in normotensive Chinese adults.

机构信息

Department of Endocrinology, Wuhan General Hospital of Guangzhou Command, Wuhan, PR China.

出版信息

Clin Chim Acta. 2015 Feb 20;441:122-6. doi: 10.1016/j.cca.2014.12.031. Epub 2014 Dec 26.

DOI:10.1016/j.cca.2014.12.031

PMID:25545230

Abstract

BACKGROUND

Although both serum gamma-glutamyltransferase (GGT) and uric acid are correlated with hypertension, studies on the association between serum GGT and uric acid in normotensive individuals are rare. In this study, we tried to reveal this relationship in normotensive Chinese adults.

METHODS

Four hundred seven normotensive adults were recruited. The subjects were divided into 3 subgroups according to serum GGT tertiles. Anthropometric parameters as well as systolic blood pressure (SBP), diastolic blood pressure (DBP), uric acid, GGT, alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood glucose, blood lipids, and fasting insulin were measured. Insulin resistance was assessed using HOMA-IR index.

RESULTS

Uric acid was increased in parallel with increasing serum GGT (P<0.001). After correction for age, sex, smoking and alcohol consumption, serum GGT was positively associated with uric acid (r=0.42, P<0.001), SBP (r=0.22, P<0.001), and DBP (r=0.19, P<0.001). When compared with lowest GGT tertile, the odds ratio of the middle tertile for the increased serum uric acid was 3.43 (95% CI, 1.39-8.47) and 7.29 (95% CI, 1.57-33.82) for the highest tertile after adjustment for age, sex, BMI, smoking, alcohol consumption, SBP, DBP, creatinine and HOMA-IR.

CONCLUSIONS

Serum GGT is strongly associated with the increased uric acid concentrations in normotensive Chinese adults.

摘要

背景

虽然血清γ-谷氨酰转移酶（GGT）和尿酸均与高血压相关，但有关血压正常个体血清 GGT 与尿酸之间关系的研究较少。本研究旨在探讨血压正常的中国成年人中血清 GGT 与尿酸之间的关系。

方法

共纳入 407 例血压正常的成年人。根据血清 GGT 三分位值将受试者分为 3 组。测量受试者的人体测量学参数及收缩压（SBP）、舒张压（DBP）、尿酸、GGT、丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）、血糖、血脂和空腹胰岛素。采用 HOMA-IR 指数评估胰岛素抵抗。

结果

随着血清 GGT 的升高，尿酸呈平行升高（P<0.001）。校正年龄、性别、吸烟和饮酒因素后，血清 GGT 与尿酸（r=0.42，P<0.001）、SBP（r=0.22，P<0.001）和 DBP（r=0.19，P<0.001）呈正相关。与最低 GGT 三分位组相比，中三分位组血清尿酸升高的比值比为 3.43（95%可信区间，1.39-8.47），最高三分位组为 7.29（95%可信区间，1.57-33.82），校正年龄、性别、BMI、吸烟、饮酒、SBP、DBP、肌酐和 HOMA-IR 后。