评估Epiphany根管封闭剂在大鼠皮下组织中的生物相容性。

Assessment of the biocompatibility of Epiphany root canal sealer in rat subcutaneous tissues.

作者信息

de Campos-Pinto Mônica Maria Denadae, de Oliveira Danilo Alessandro, Versiani Marco Aurélio, Silva-Sousa Yara Teresinha Correa, de Sousa-Neto Manoel Damião, da Cruz Perez Danyel Elias

机构信息

School of Dentistry, University of Ribeirao Preto, Ribeirao Preto, Brazil.

出版信息

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 May;105(5):e77-81. doi: 10.1016/j.tripleo.2008.01.024.

DOI:10.1016/j.tripleo.2008.01.024

PMID:18442740

Abstract

OBJECTIVE

The aim of this study was to evaluate the biocompatibility of the root canal sealer Epiphany in rat subcutaneous tissues.

STUDY DESIGN

Polyethylene tubes were filled with the sealer (I: Epiphany; II: photoactivated Epiphany; III: Epiphany associated with self-etch primer; IV: photoactivated Epiphany associated with primer; and V: control group) and later implanted into 4 different regions of the dorsum of 15 adult male rats (Rattus novergicus, Albinus Wistar). After 7, 21, and 42 days, 5 animals were killed, obtaining 4 samples per group, in addition to the control group, at each analyzed time.

RESULTS

In all periods, Epiphany induced a mild inflammatory reaction. However, in group II, in which the primer was not used, extensive necrosis and a moderate to intense inflammatory reaction were observed, mainly after 7 and 21 days.

CONCLUSION

Epiphany sealer appears biocompatible when tested on rat subcutaneous tissues.

摘要

目的

本研究旨在评估根管封闭剂Epiphany在大鼠皮下组织中的生物相容性。

研究设计

将聚乙烯管填充密封剂（I组：Epiphany；II组：光活化Epiphany；III组：Epiphany与自酸蚀底漆联合使用；IV组：光活化Epiphany与底漆联合使用；V组：对照组），随后植入15只成年雄性大鼠（挪威大鼠，白化Wistar大鼠）背部的4个不同区域。在7天、21天和42天后，每组处死5只动物，除对照组外，在每个分析时间点每组获取4个样本。