新型牙髓糊剂在大鼠皮下组织引起的组织反应的形态学分析
Morphological analysis of tissue reaction caused by a new endodontic paste in subcutaneous tissue of rats.
作者信息
Marques André Af, Sponchiado Emilio C, Garcia Lucas Fr, Garrido Angela Db, França Suzelei C, Lia Raphael Cc
机构信息
Department of Endodontics, School of Dentistry, Federal University of Amazonas, Manaus, AM, Brazil.
出版信息
J Conserv Dent. 2011 Jul;14(3):309-13. doi: 10.4103/0972-0707.85823.
AIM
To assess the biocompatibility of an experimental endodontic paste based on the ethyl acetate fraction of Pothomorphe umbellata + calcium hydroxide, using propylene glycol as vehicle, in connective tissue of rats.
MATERIALS AND METHODS
Fifteen rats had four polyethylene tubes implanted in their backs, with each one containing the experimental paste. The tube side was considered the control group. After 7, 21, and 42 days, animals were euthanized.
RESULTS
Intense inflammatory reaction was noticed after 7 days for experimental paste and it was moderate for control group. At 21 days, the inflammatory reaction was moderate for experimental paste and discrete for control group; and at 42 days, it was discrete for experimental paste and control group. Statistical analysis (Dunn's test, P < 0.01) demonstrated significant difference between the fibrous capsule area at 7 and 42 days (P > 0.01) for experimental paste.
CONCLUSIONS
Experimental endodontic paste presented satisfactory tissue reaction in the connective tissue of rats.
目的
以聚伞花胡椒的乙酸乙酯提取物+氢氧化钙为基础，以丙二醇作为赋形剂，评估一种实验性牙髓糊剂在大鼠结缔组织中的生物相容性。
材料与方法
15只大鼠背部植入4根聚乙烯管，每根管子中含有实验性糊剂。管子一侧作为对照组。7天、21天和42天后，对动物实施安乐死。
结果
7天时，实验性糊剂出现强烈炎症反应，对照组为中度炎症反应。21天时，实验性糊剂的炎症反应为中度，对照组为轻度；42天时，实验性糊剂和对照组均为轻度。统计分析（邓恩检验，P<0.01）表明，实验性糊剂在7天和42天时纤维囊面积存在显著差异（P>0.01）。
结论
实验性牙髓糊剂在大鼠结缔组织中呈现出令人满意的组织反应。
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