Bilska Anna, Dudek Magdalena, Iciek Małgorzata, Kwiecień Inga, Sokołowska-Jezewicz Maria, Filipek Barbara, Włodek Lidia
The Chair of Medical Biochemistry, Jagiellonian University, Collegium Medicum, Kopernika 7, PL 31-034 Kraków, Poland.
Pharmacol Rep. 2008 Mar-Apr;60(2):225-32.
This work aimed to investigate the effect of lipoic acid (LA) on sulfane sulfur (S()) level and rhodanese activity in rat tissues. In vitro studies conduced so far have indicated that dihydrolipoic acid serves as an S() acceptor in the rhodanese-catalyzed S() transfer. This study revealed a significant increase in S() level and rhodanese activity in the heart, liver and kidney homogenates from rats that had previously been treated intraperitoneally with LA. It demonstrated for the first time in vivo that biological activity of lipoate might be connected with anaerobic cysteine metabolism to S(*) and with rhodanese activity.
这项工作旨在研究硫辛酸（LA）对大鼠组织中硫烷硫（S()）水平和硫氰酸酶活性的影响。迄今为止进行的体外研究表明，二氢硫辛酸在硫氰酸酶催化的S()转移中作为S()受体。本研究显示，先前经腹腔注射LA处理的大鼠的心脏、肝脏和肾脏匀浆中，S()水平和硫氰酸酶活性显著增加。首次在体内证明硫辛酸的生物学活性可能与半胱氨酸厌氧代谢生成S(*)以及硫氰酸酶活性有关。
