Department of Molecular Medical Microbiology, Chair of Microbiology, Jagiellonian University, Medical College, Cracow, Poland.
Chair of Epidemiology and Preventive Medicine, Department of Epidemiology, Jagiellonian University Medical College, Cracow, Poland.
Pol J Microbiol. 2021 Dec;70(4):521-526. doi: 10.33073/pjm-2021-050. Epub 2021 Dec 23.
is associated with various infections, for which the treatment can be complex. Lipoic acid (LA) plays a role as a cofactor in eukaryotes, most Bacteria, and some Archea. Research of recent years has increasingly pointed to the therapeutic properties of exogenously supplemented LA. The present study was conducted on 40 strains of cultured with the following LA concentrations: 1,200 μg/ml, 120 μg/ml, and 12 μg/ml. The bacterial colonies of each strain were counted and expressed as the number of colony-forming units/ml (CFU). The number of CFU in strains obtained in the presence of LA was compared with the number of CFU in the strains grown in the media without LA. The obtained results indicated that the presence of LA in the medium did not affect the growth of . The investigation of the influence of LA on the growth and survival of microbial cells not only allows for obtaining an answer to the question of whether LA has antimicrobial activity and, therefore, can be used as a drug supporting the treatment of patients infected with a given pathogenic microorganism. Such studies are also crucial for a better understanding of LA metabolism in the microbial cells, which is also important for the search for new antimicrobial drugs. This research is, therefore, an introduction to such further studies.
它与各种感染有关，其治疗可能很复杂。硫辛酸（LA）在真核生物、大多数细菌和一些古菌中作为辅助因子发挥作用。近年来的研究越来越多地指出外源性补充 LA 的治疗特性。本研究在以下 LA 浓度下培养了 40 株 ：1200μg/ml、120μg/ml 和 12μg/ml。对每种菌株的细菌菌落进行计数，并表示为每毫升菌落形成单位（CFU）的数量。将存在 LA 时获得的菌株的 CFU 数量与在不含 LA 的培养基中生长的菌株的 CFU 数量进行比较。结果表明，培养基中存在 LA 不会影响 的生长。研究 LA 对微生物细胞生长和存活的影响不仅可以回答 LA 是否具有抗菌活性，因此可以用作支持治疗感染特定病原体的患者的药物的问题。此类研究对于更好地了解微生物细胞中 LA 的代谢也很重要，这对于寻找新的抗菌药物也很重要。因此，这项研究是对进一步研究的介绍。
