Ito Tomoki, Ozaki Yoshio, Shimamoto Keiko, Amuro Hideki, Tanijiri Tsutomu, Yokoi Takashi, Son Yonsu, Tajima Kenichirou, Fukuhara Shirou
First Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi, Osaka 570-8506, Japan.
Mod Rheumatol. 2008;18(4):407-10. doi: 10.1007/s10165-008-0065-9. Epub 2008 Apr 29.
Adult-onset Still's disease (AOSD) is a rheumatoid disorder characterized by high fever, polyarthritis, leukocytosis, hyperferritinaemia, and mild liver involvement. We describe the case of a patient with AOSD with severe liver dysfunction. His serum levels of interleukin-10 and 18 showed a similar trend to his disease activity. Drug lymphocyte stimulation tests were positive for three drugs in the patient. Hypercytokinaemia was controlled by plasma exchange therapy.
成人斯蒂尔病（AOSD）是一种类风湿性疾病，其特征为高热、多关节炎、白细胞增多、高铁蛋白血症和轻度肝脏受累。我们描述了一例患有严重肝功能障碍的AOSD患者的病例。他的白细胞介素-10和18血清水平与疾病活动呈现相似趋势。该患者的药物淋巴细胞刺激试验对三种药物呈阳性。高细胞因子血症通过血浆置换疗法得到控制。
