Jeunemaitre Xavier
INSERM U772, Collège de France, 11 place Marcelin Berthelot, Paris, France.
J Mol Med (Berl). 2008 Jun;86(6):637-41. doi: 10.1007/s00109-008-0344-0. Epub 2008 Apr 29.
The genes coding for the renin angiotensin system have been extensively studied. During the last 15 years, informative markers and functional polymorphisms have been identified, and numerous linkage and association studies have been performed in cardiovascular diseases, especially human hypertension. This mini-review aims to summarize the main findings observed for each component of this enzymatic cascade taken alone or in combination, with an emphasis on the most recent or innovative studies.
编码肾素-血管紧张素系统的基因已得到广泛研究。在过去15年中，已鉴定出信息性标记物和功能性多态性，并且在心血管疾病，尤其是人类高血压方面进行了大量的连锁和关联研究。本综述旨在总结单独或联合研究该酶促级联反应各组分时观察到的主要发现，重点关注最新或创新性研究。
