Arpino C, Gattinara G Castelli, Rosso M, Pelliccia A, Fariello G, Curatolo P
Department of Neurosciences, Paediatric Neurology Unit, Tor Vergata University of Rome, Rome, Italy.
J Neurovirol. 2008 Apr;14(2):173-6. doi: 10.1080/13550280801908166.
Although cytomegalovirus (CMV) congenital infection is more severe in children born to women with primary infection, neurological symptoms have also been observed in infants born to mothers with preconceptional immunity. The authors describe for the first time a case of severe cortical development disorder associated with multiple abnormalities of the white matter, occurring in the second-born child of a woman found to be positive for anti-CMV immunoglobulin G (IgG) before pregnancy. CMV DNA was detected in the urine and blood of the infant. These findings indicate that the neurological outcome of CMV infection may be severe also in infants born to women with preexisting immunity.
尽管巨细胞病毒（CMV）先天性感染在原发性感染女性所生儿童中更为严重，但在孕前具有免疫力的母亲所生婴儿中也观察到了神经症状。作者首次描述了一例与白质多处异常相关的严重皮质发育障碍病例，该病例发生在一名在怀孕前抗CMV免疫球蛋白G（IgG）检测呈阳性的女性的第二个孩子身上。在婴儿的尿液和血液中检测到了CMV DNA。这些发现表明，在已有免疫力的女性所生婴儿中，CMV感染的神经学后果也可能很严重。
