Kola B
Centre for Endocrinology, Barts and London School of Medicine and Dentistry, University of London, London, UK.
J Neuroendocrinol. 2008 Jul;20(7):942-51. doi: 10.1111/j.1365-2826.2008.01745.x. Epub 2008 Apr 28.
AMP-activated protein kinase is a key enzyme in the regulation of energy metabolism. Its activation has pleiotropic effects in multiple tissues, including increased fatty acid oxidation, glucose uptake and glycolysis, as well as the inhibition of fatty acid and glycogen synthesis and gluconeogenesis, and stimulation of mitochondrial biogenesis. Recently, the AMP-activated protein kinase (AMPK) has also emerged as a regulator of appetite, contributing to the control of energy metabolism at both cell and the whole body levels. Pharmacological and genetic activation or inhibition of hypothalamic AMPK lead to increased or reduced food intake, respectively. AMPK appears to play a role in hypothalamic glucose and nutrient sensing and numerous studies have suggested a role for AMPK in mediating the orexigenic or anorexigenic effects of various endogenous and exogenous substances.
AMP激活的蛋白激酶是能量代谢调节中的关键酶。其激活在多个组织中具有多效性作用，包括增加脂肪酸氧化、葡萄糖摄取和糖酵解，以及抑制脂肪酸和糖原合成及糖异生，并刺激线粒体生物发生。最近，AMP激活的蛋白激酶（AMPK）也已成为食欲的调节因子，在细胞和全身水平上对能量代谢的控制发挥作用。下丘脑AMPK的药理学和基因激活或抑制分别导致食物摄入量增加或减少。AMPK似乎在下丘脑葡萄糖和营养物质感知中发挥作用，并且大量研究表明AMPK在介导各种内源性和外源性物质的促食欲或抑食欲作用中发挥作用。
