Mueller Dirk H, Wiseman Virginia, Bakusa Dankom, Morgah Kodjo, Daré Aboudou, Tchamdja Potougnima
Health Economics and Financing Programme, Department of Public Health and Policy, London School of Hygiene and Tropical Medicine, Keppel St., London WC1E 7HT, UK.
Malar J. 2008 Apr 29;7:73. doi: 10.1186/1475-2875-7-73.
To evaluate the cost-effectiveness of the first nationwide delivery of long-lasting insecticide-treated nets (LLITNs) as part of the 2004 measles vaccination campaign in Togo to all children between nine months and five years.
An incremental approach was used to calculate the economic costs and effects from a provider perspective. Effectiveness was estimated in terms of malaria cases averted, deaths averted and Disability-Adjusted Life Years (DALYs) averted. Malaria cases were modelled using regional estimates. Programme and treatment costs were derived through reviews of financial records and interviews with key stakeholders. Uncertain variables were subjected to a univariate sensitivity analysis.
Assuming equal attribution of shared costs between the LLITN distribution and the measles vaccination, the net costs per LLITN distributed were 4.41 USD when saved treatment costs were taken into account. Assuming a constant utilization of LLITNs by the target group over three years, 1.2 million cases could be prevented at a net cost per case averted of 3.26 USD. The net costs were 635 USD per death averted and 16.39 USD per DALY averted, respectively.
The costs per case, death and DALY averted are well within commonly agreed benchmarks set by other malaria prevention studies. Varying transmission levels are shown to have a significant impact on cost-effectiveness ratios. Results also suggest that substantial efficiency gains may be derived from the joint delivery of vaccination campaigns and malaria interventions.
为评估2004年多哥全国范围内作为麻疹疫苗接种运动一部分向所有9个月至5岁儿童发放长效驱虫蚊帐(LLITN)的成本效益。
采用增量法从提供者角度计算经济成本和效果。效果根据避免的疟疾病例、避免的死亡和避免的伤残调整生命年(DALY)来估计。疟疾病例使用区域估计数进行建模。方案和治疗成本通过审查财务记录和与关键利益相关者访谈得出。对不确定变量进行单因素敏感性分析。
假设LLITN分发和麻疹疫苗接种之间的共享成本平均分摊,考虑到节省的治疗成本,每分发一顶LLITN的净成本为4.41美元。假设目标群体在三年内持续使用LLITN,可预防120万例病例,每避免一例病例的净成本为3.26美元。每避免一例死亡的净成本分别为635美元,每避免一个DALY的净成本为16.39美元。
每避免一例病例、一例死亡和一个DALY的成本均在其他疟疾预防研究设定的普遍认可基准范围内。不同的传播水平对成本效益比有重大影响。结果还表明,联合开展疫苗接种运动和疟疾干预措施可大幅提高效率。