Al Wakeel Jamal S, Memon Nawaz Ali, Chaudhary AbdulRauf, Mitwalli Ahmad H, Tarif Nauman, Isnani Arthur, Hammad Durdana
Department of Medicine, King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia.
Saudi J Kidney Dis Transpl. 2008 May;19(3):361-70.
This is the first report from Saudi Arabia studying the normal reference intervals in adult Saudi subjects and evaluating serum cystatin C as a prospective marker for the assessment of the glomerular filtration rate (GFR). Three hundred healthy adult Saudi subjects including 156 males (52%) and 144 females (48%), with a mean age of 31.21 +/- 9.82 years were prospectively studied to establish normal reference ranges for cystatin C. A total of 68.34% of the study patients were in the age-group of 21-40 years. The mean serum cystatin C in the 300 healthy subjects was 0.751 +/- 0.11 mg/L (0.50 - 1.09), increasing gradually with age: it was 0.738 +/- 0.11 mg/L (0.51 - 1.09) in the age-group 21 - 30 years and 0.807 +/- 0.12 (0.51 - 1.09) among subjects who were > 50 years of age. The mean serum cystatin C in females (0.778 +/- 0.118 mg/L) was significantly hig-her than in males (0.726 +/- 0.095 mg/L) (p < 0.0001). The serum cystatin C level was within the defined reference range of 0.53 - 0.95 mg/L in 95% of the subjects with a mean value of 0.74 +/- 0.097 mg/L, and was falling within the 95% confidence interval of 0.73865 - 0.7637 mg/L, and with 98.84% area under the curve (AUC). All the other renal function markers (urea, serum creatinine, calculated GFR, BMI) among the studied subjects were within the normal reference ranges for adult Saudi population. The serum cystatin C level had a significant correlation with the body mass index (BMI) (r = 0.155; p = 0.007) and a correlation with serum creatinine as well (r = 0.009; p = 0.873). It showed a negative correlation with calculated GFR as per Cockroft-Gault equation (r = - 0.101; p = 0.083).
这是沙特阿拉伯的首份报告，研究沙特成年受试者的正常参考区间，并评估血清胱抑素C作为评估肾小球滤过率（GFR）的前瞻性标志物。对300名健康的沙特成年受试者进行了前瞻性研究，以确定胱抑素C的正常参考范围，其中包括156名男性（52%）和144名女性（48%），平均年龄为31.21±9.82岁。共有68.34%的研究患者年龄在21至40岁之间。300名健康受试者的血清胱抑素C平均水平为0.751±0.11mg/L（0.50 - 1.09），并随年龄逐渐升高：在21至30岁年龄组中为0.738±0.11mg/L（0.51 - 1.09），在年龄大于50岁的受试者中为0.807±0.12（0.51 - 1.09）。女性的血清胱抑素C平均水平（0.778±0.118mg/L）显著高于男性（0.726±0.095mg/L）（p < 0.0001）。95%的受试者血清胱抑素C水平在0.53 - 0.9 mg/L的定义参考范围内，平均值为0.74±0.097mg/L，落在0.73865 - 0.7637mg/L的95%置信区间内，曲线下面积（AUC）为98.84%。研究对象中的所有其他肾功能标志物（尿素、血清肌酐、计算的GFR、BMI）均在沙特成年人群的正常参考范围内。血清胱抑素C水平与体重指数（BMI）显著相关（r = 0.155；p = 0.007），与血清肌酐也有相关性（r = 0.009；p = 0.873）。根据Cockcroft - Gault方程，它与计算的GFR呈负相关（r = - 0.101；p = 0.083）。
