Milam Joel, McConnell Rob, Yao Ling, Berhane Kiros, Jerrett Michael, Richardson Jean
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA.
J Asthma. 2008 May;45(4):319-23. doi: 10.1080/02770900801930277.
Although studies indicate that psychological stress is linked with asthma morbidity, it is unknown whether stress is associated with the incidence of asthma symptoms.
In a cohort of 5- to 6-year-old school children participating in the southern California Children's Health Study, we evaluated parent-reported wheeze in the child using a standardized questionnaire and perceived parental stress at study entry. Wheeze in the child was evaluated one year later. Analyses were restricted to children without asthma at study entry (N = 2,888, of whom 286 had wheeze at follow-up).
There was an increase in wheeze across an interquartile range of parent stress (odds ratio [OR] 1.18; 95% confidence interval [CI] 0.99, 1.42). Parent stress was associated with wheeze among children with no parental asthma (OR 1.24; CI 0.99, 1.55) and among boys (OR 1.34; CI 1.04, 1.74), but not among girls or children with parental asthma. Among boys with no parental asthma there was a strong dose-response relationship, and in the top quartile of stress the OR was 2.76 (CI 1.39, 5.51) compared to the bottom quartile.
Parental stress increases the risk of childhood wheeze among children with no parental history of asthma, especially among boys. These results suggest that the influence of psychosocial factors on asthma, such as stress and social environment, deserve increased attention.
尽管研究表明心理压力与哮喘发病率相关，但压力是否与哮喘症状的发生率有关尚不清楚。
在参与南加州儿童健康研究的5至6岁学龄儿童队列中，我们使用标准化问卷评估家长报告的孩子喘息情况，并在研究开始时评估家长感知到的压力。一年后对孩子的喘息情况进行评估。分析仅限于研究开始时无哮喘的儿童（N = 2888，其中286名在随访时有喘息症状）。
在家长压力的四分位间距范围内，喘息情况有所增加（比值比[OR] 1.18；95%置信区间[CI] 0.99，1.42）。家长压力与无父母哮喘的儿童喘息有关（OR 1.24；CI 0.99，1.55），与男孩喘息有关（OR 1.34；CI 1.04，1.
