Asl Marjan Nassiri, Hosseinzadeh Hossein
Department of Pharmacology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, IR Iran.
Phytother Res. 2008 Jun;22(6):709-24. doi: 10.1002/ptr.2362.
The roots and rhizomes of licorice (Glycyrrhiza) species have long been used worldwide as a herbal medicine and natural sweetener. Licorice root is a traditional medicine used mainly for the treatment of peptic ulcer, hepatitis C, and pulmonary and skin diseases, although clinical and experimental studies suggest that it has several other useful pharmacological properties such as antiinflammatory, antiviral, antimicrobial, antioxidative, anticancer activities, immunomodulatory, hepatoprotective and cardioprotective effects. A large number of components have been isolated from licorice, including triterpene saponins, flavonoids, isoflavonoids and chalcones, with glycyrrhizic acid normally being considered to be the main biologically active component. This review summarizes the phytochemical, pharmacological and pharmacokinetics data, together with the clinical and adverse effects of licorice and its bioactive components.
甘草(甘草属)植物的根和根茎长期以来在全球范围内被用作草药和天然甜味剂。甘草根是一种传统药物,主要用于治疗消化性溃疡、丙型肝炎以及肺部和皮肤疾病,尽管临床和实验研究表明它还具有其他一些有益的药理特性,如抗炎、抗病毒、抗菌、抗氧化、抗癌活性、免疫调节、保肝和心脏保护作用。已从甘草中分离出大量成分,包括三萜皂苷、黄酮类化合物、异黄酮类化合物和查耳酮,甘草酸通常被认为是主要的生物活性成分。本综述总结了甘草及其生物活性成分的植物化学、药理和药代动力学数据,以及临床和不良反应。