表观遗传调控：缓慢且全局，灵活且局部。
Epigenetic control: slow and global, nimble and local.
作者信息
Cheng Christine S, Johnson Tracy L, Hoffmann Alexander
机构信息
Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA.
出版信息
Genes Dev. 2008 May 1;22(9):1110-4. doi: 10.1101/gad.1677008.
Abstract
The regulation of gene expression involves multiple levels of control, from those that are inheritable to those that are highly responsive to environmental changes. In this issue of Genes & Development, Dong and colleagues (pp. 1159-1173) demonstrate that the dynamically controlled immune response transcription factor NF-kappaB may, in fact, have a role in regulating heterochromatin and gene expression at large distances from its actual target sequences and genes.
摘要
基因表达的调控涉及多个层面的控制，从可遗传的层面到对环境变化高度敏感的层面。在本期《基因与发育》中，董及其同事（第1159 - 1173页）证明，动态控制的免疫反应转录因子NF-κB实际上可能在远离其实际靶序列和基因的区域调控异染色质和基因表达。
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2
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3
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Cell. 2007 Sep 21;130(6):1083-94. doi: 10.1016/j.cell.2007.08.019. Epub 2007 Sep 6.
4
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