Kato I, Nomura A, Stemmermann G N, Chyou P H
Japan-Hawaii Cancer Study, Kuakini Medical Center, Honolulu 96817.
Cancer Epidemiol Biomarkers Prev. 1991 Nov-Dec;1(1):51-5.
In this prospective study, the association between hematocrit values measured in 1965-68 and subsequent cancer incidence was studied among 7737 Japanese-American men in Hawaii. With an increase in hematocrit levels, there was an increasing risk for lung cancer, especially squamous or small cell type, and for kidney cancer. However, a statistically significant trend remained only for kidney cancer after adjusting for smoking history. The relative risk for kidney cancer was 4.94 (95% confidence interval, 1.03-23.63) for subjects with hematocrit values of 47 or higher compared with those with hematocrit values of 43 or lower. In contrast, the risk of oral-pharyngeal cancer decreased with increasing hematocrit levels. With adjustment for cigarette smoking and alcohol intake, the relative risk for oral-pharyngeal cancer was 0.20 (95% confidence interval, 0.04-0.88) for subjects with hematocrit values of 47 or higher compared with those with hematocrit values of 43 or lower. The association with kidney or oral-pharyngeal cancer was not affected by the time interval between examination and diagnosis of these cancers (< or = 10 and > 10 years). Erythropoietin production by kidney tumors and micronutrient deficiencies in oral-pharyngeal cancer cases may partially account for these results.
在这项前瞻性研究中，我们对夏威夷7737名日裔美国男性1965 - 1968年测量的血细胞比容值与随后的癌症发病率之间的关联进行了研究。随着血细胞比容水平的升高，患肺癌尤其是鳞状或小细胞型肺癌以及肾癌的风险增加。然而，在调整吸烟史后，仅肾癌存在统计学显著趋势。血细胞比容值为47或更高的受试者与血细胞比容值为43或更低的受试者相比，肾癌的相对风险为4.94（95%置信区间，1.03 - 23.63）。相反，口咽癌的风险随着血细胞比容水平的升高而降低。在调整吸烟和饮酒量后，血细胞比容值为47或更高的受试者与血细胞比容值为43或更低的受试者相比，口咽癌的相对风险为0.20（95%置信区间，0.04 - 0.88）。与肾癌或口咽癌的关联不受这些癌症检查与诊断之间时间间隔（≤10年和>10年）的影响。肾肿瘤产生促红细胞生成素以及口咽癌病例中的微量营养素缺乏可能部分解释了这些结果。
