Dhillon V, Latchman D, Isenberg D
Department of Biochemistry, UCL, London, UK.
Lupus. 1991 Nov;1(1):3-8. doi: 10.1177/096120339100100102.
This review briefly defines the heat shock proteins (hsps), their classification and their functions. The hypothesis that links hsps to the development of autoimmunity is explored, together with the rationale for investigation of the relationship between hsps and systemic lupus erythematosus (SLE). Thus, published work on this subject falls into three main categories: the overexpression of hsps in SLE, the development of autoantibodies to hsps in SLE, and the surface expression of hsps in peripheral blood mononuclear cells in SLE. This work is reviewed in detail. In conclusion, we describe areas for further study and outline ways in which this is being approached.
本综述简要定义了热休克蛋白（hsps）、其分类及其功能。探讨了将热休克蛋白与自身免疫性疾病发展联系起来的假说，以及研究热休克蛋白与系统性红斑狼疮（SLE）之间关系的基本原理。因此，关于该主题的已发表研究主要分为三大类：SLE中热休克蛋白的过度表达、SLE中针对热休克蛋白的自身抗体的产生，以及SLE中外周血单个核细胞中热休克蛋白的表面表达。对这项工作进行了详细综述。最后，我们描述了有待进一步研究的领域，并概述了开展此项研究的方法。
