Bond Jeremy S, Duncan Jonathan A L, Sattar Abdul, Boanas Adam, Mason Tracey, O'Kane Sharon, Ferguson Mark W J
Manchester, United Kingdom From the University of Manchester and Renovo, Ltd.
Plast Reconstr Surg. 2008 May;121(5):1650-1658. doi: 10.1097/PRS.0b013e31816a9f6f.
The natural history of scar maturation in humans has never been formally described from either a clinical or a histologic standpoint.
The maturation of incisional scars was observed in 58 healthy male volunteers who each had 2 x 1-cm incisional wounds created on the inner aspect of both upper arms. The resulting scars were photographed digitally at monthly intervals for 12 months and excised for histologic analysis at specific time points. All histologic specimens were stained using Masson's trichrome and reviewed together with the corresponding digital clinical scar images to produce macroscopic and microscopic descriptions of the maturation process.
Three distinct groups, each displaying a different rate of longitudinal progression of scar maturation, were identified from within the study group. The majority of volunteers belonged to a "representative" subset but distinct "poor" and "excellent" subsets were also identified. The poor subset invariably contained volunteers younger than 30 years of age, whereas the majority of the excellent subset comprised subjects older than 55 years of age.
Scar maturation occurs as a series of defined macroscopic and microscopic stages over the course of 1 year. The rate of scar maturation varied within the study group, with older subjects (>55 years) displaying accelerated maturation, whereas a prolonged high turnover state and a retarded rate of maturation were observed in younger subjects (<30 years).
从临床或组织学角度，人类瘢痕成熟的自然史从未被正式描述过。
在58名健康男性志愿者身上观察切口瘢痕的成熟情况，每名志愿者双臂内侧均有2个1厘米×1厘米的切口伤口。在12个月内每月对形成的瘢痕进行数码拍照，并在特定时间点切除瘢痕进行组织学分析。所有组织学标本均用马森三色染色法染色，并与相应的临床瘢痕数码图像一起进行检查，以对成熟过程进行宏观和微观描述。
在研究组中确定了三个不同的组，每组瘢痕成熟的纵向进展速率不同。大多数志愿者属于一个“代表性”亚组，但也确定了不同的“差”和“优”亚组。差亚组总是包含年龄小于30岁的志愿者，而优亚组的大多数受试者年龄大于55岁。
瘢痕成熟在1年的时间内呈现为一系列明确的宏观和微观阶段。研究组内瘢痕成熟速率各不相同，年龄较大的受试者（>55岁）瘢痕成熟加速，而年龄较小的受试者（<30岁）则观察到较长时间的高周转状态和成熟速率延缓。
