用于三维血管化组织发育的微流控技术
Microfluidic techniques for development of 3D vascularized tissue.
作者信息
Hasan Anwarul, Paul Arghya, Vrana Nihal E, Zhao Xin, Memic Adnan, Hwang Yu-Shik, Dokmeci Mehmet R, Khademhosseini Ali
机构信息
Biomedical Engineering, and Department of Mechanical Engineering, American University of Beirut, Beirut 1107 2020, Lebanon; Biomaterials Innovation Research Center, Division of Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Biomaterials Innovation Research Center, Division of Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
出版信息
Biomaterials. 2014 Aug;35(26):7308-25. doi: 10.1016/j.biomaterials.2014.04.091. Epub 2014 Jun 3.
Development of a vascularized tissue is one of the key challenges for the successful clinical application of tissue engineered constructs. Despite the significant efforts over the last few decades, establishing a gold standard to develop three dimensional (3D) vascularized tissues has still remained far from reality. Recent advances in the application of microfluidic platforms to the field of tissue engineering have greatly accelerated the progress toward the development of viable vascularized tissue constructs. Numerous techniques have emerged to induce the formation of vascular structure within tissues which can be broadly classified into two distinct categories, namely (1) prevascularization-based techniques and (2) vasculogenesis and angiogenesis-based techniques. This review presents an overview of the recent advancements in the vascularization techniques using both approaches for generating 3D vascular structure on microfluidic platforms.
构建血管化组织是组织工程构建体成功临床应用的关键挑战之一。尽管在过去几十年中付出了巨大努力，但建立一个开发三维（3D）血管化组织的金标准仍远未实现。微流控平台在组织工程领域应用的最新进展极大地加速了可行的血管化组织构建体的开发进程。已经出现了许多诱导组织内血管结构形成的技术，这些技术大致可分为两类，即（1）基于预血管化的技术和（2）基于血管发生和血管生成的技术。本文综述了利用这两种方法在微流控平台上生成3D血管结构的血管化技术的最新进展。
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