Werbrouck H, Botteldoorn N, Ceelen L, Decostere A, Uyttendaele M, Herman L, Van Coillie E
Flemish Government, Institute for Agricultural and Fisheries Research, Unit Technology and Food, Melle, Belgium.
Zoonoses Public Health. 2008 Jun;55(5):242-8. doi: 10.1111/j.1863-2378.2008.01127.x.
In this study, the virulence heterogeneity of Listeria monocytogenes serotype 4b strains of different origins was analysed on different levels. On one hand, the survival of L. monocytogenes strains in synthetic gastric fluid was studied. On the other hand, the pathogenic potential of strains with different inlB expression levels was analysed in an A/J mouse model for gastrointestinal listeriosis. Differences in survival capacity in gastric fluid and in in vivo virulence potential were observed between the tested strains. No clear correlation between the origin and the obtained data could be made. However, these results confirm the existence of heterogeneity in virulence potential of L. monocytogenes serotype 4b strains.
在本研究中，对不同来源的单核细胞增生李斯特菌4b血清型菌株的毒力异质性进行了不同层面的分析。一方面，研究了单核细胞增生李斯特菌菌株在合成胃液中的存活情况。另一方面，在A/J小鼠胃肠道李斯特菌病模型中分析了不同inlB表达水平菌株的致病潜力。在所测试的菌株之间观察到了胃液存活能力和体内毒力潜力的差异。无法确定来源与所得数据之间存在明确的相关性。然而，这些结果证实了单核细胞增生李斯特菌4b血清型菌株在毒力潜力方面存在异质性。
