Kelly Bronwen N, Huckabee Maggie-Lee, Frampton Christopher M A, Jones Richard D
Van der Veer Institute for Parkinson's and Brain Research, Christchurch, New Zealand.
Int J Dev Neurosci. 2008 Aug;26(5):385-90. doi: 10.1016/j.ijdevneu.2008.03.006. Epub 2008 Mar 29.
Although the brainstem plays an important role in breathing-swallowing coordination (BSC), the role of suprabulbar structures is ill defined. Given the known decrease in global cerebral activity during sleep, the sleep-wake paradigm was used to elucidate suprabulbar influences. Non-nutritive BSC of 10 healthy human infants was monitored longitudinally during wakefulness and sleep from birth to 1 year of age. Time-locked recordings of submental muscle activity, nasal airflow, and thyroid acoustics enabled the categorization of swallows depending on the preceding and following respiratory phase. In contrast to the change in the overall pattern of BSC with age, and despite well-known marked postnatal cortical development over this time, no arousal-related differences were seen during the first year of life. This most likely reflects complete brainstem control of non-nutritive BSC in infants.
虽然脑干在呼吸-吞咽协调（BSC）中起着重要作用，但延髓以上结构的作用尚不明确。鉴于已知睡眠期间全脑活动会减少，因此采用睡眠-觉醒模式来阐明延髓以上结构的影响。对10名健康人类婴儿从出生到1岁期间在清醒和睡眠状态下的非营养性BSC进行了纵向监测。通过对颏下肌肉活动、鼻气流和喉部声学进行锁时记录，能够根据前后呼吸阶段对吞咽进行分类。与BSC总体模式随年龄的变化不同，尽管在此期间出生后皮质有明显发育，但在生命的第一年未观察到与觉醒相关的差异。这很可能反映出婴儿非营养性BSC完全受脑干控制。
