女性阻塞性睡眠呼吸暂停、夜尿症与白天膀胱过度活动症之间的关系。
The relationship between obstructive sleep apnea, nocturia, and daytime overactive bladder syndrome in women.
作者信息
Lowenstein Lior, Kenton Kimberly, Brubaker Linda, Pillar Giora, Undevia Nidhi, Mueller Elizabeth R, FitzGerald Mary Pat
机构信息
Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Loyola Medical Center, Chicago, IL 60153, USA.
出版信息
Am J Obstet Gynecol. 2008 May;198(5):598.e1-5. doi: 10.1016/j.ajog.2008.02.024.
OBJECTIVE
The purpose of this study was to corroborate the association between obstructive sleep apnea (OSA) and nocturia in a clinical sample of urogynecologic patients and to explore whether night-time urine concentration predicts the presence of OSA.
STUDY DESIGN
Patients with nocturia and control subjects underwent a home sleep study, completed validated nocturia questionnaires, and provided evening and morning urine specimens that were analyzed for osmolarity.
RESULTS
Twenty-one patients with nocturia (16 of whom also had daytime overactive bladder [OAB] symptoms) and 10 control subjects were studied. OSA was present in 17 of 21 women (81%) with nocturia: 13 women (81%) with OAB, 4 women (80%) with nocturia/no OAB, and 4 control subjects (40%; P < .001). The percentage of rapid eye movement sleep time was correlated inversely with nocturic frequency (rho = -.51; P < .004). The presence of diluted nighttime urine in a patient with nocturia was 88% sensitive for the presence of OSA.
CONCLUSION
We should consider a diagnosis of OSA in all patients with nocturia, even those patients with daytime OAB.
目的
本研究旨在证实尿妇科患者临床样本中阻塞性睡眠呼吸暂停（OSA）与夜尿症之间的关联，并探讨夜间尿液浓缩情况是否可预测OSA的存在。
研究设计
夜尿症患者和对照受试者接受家庭睡眠研究，完成经过验证的夜尿症问卷，并提供晚间和早晨的尿液样本以分析渗透压。
结果
研究了21例夜尿症患者（其中16例也有白天膀胱过度活动症[OAB]症状）和10例对照受试者。21例夜尿症女性中有17例（81%）存在OSA：13例有OAB的女性（81%），4例有夜尿症/无OAB的女性（80%），以及4例对照受试者（40%；P <.001）。快速眼动睡眠时间百分比与夜尿频率呈负相关（rho = -.51；P <.004）。夜尿症患者夜间尿液稀释对OSA存在的敏感性为88%。
结论
我们应考虑对所有夜尿症患者，甚至是有白天OAB症状的患者进行OSA诊断。
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