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挪威养老院患者中抑郁症状模式及康奈尔量表的因素分析

The pattern of depressive symptoms and factor analysis of the Cornell Scale among patients in Norwegian nursing homes.

作者信息

Barca Maria Lage, Selbaek Geir, Laks Jerson, Engedal Knut

机构信息

Norwegian Centre for Dementia Research, Centre for Ageing and Health, Department of Geriatric Medicine, Ullevaal University Hospital and Faculty of Medicine, University of Oslo, Norway.

出版信息

Int J Geriatr Psychiatry. 2008 Oct;23(10):1058-65. doi: 10.1002/gps.2033.

Abstract

BACKGROUND

Depression is more prevalent in subjects with dementia than in those without it. Due to both psychological and biological risk factors it is suggested that a bimodal distribution of depressive symptoms exists with higher prevalence rates being found among patients suffering both with mild and with severe dementia.

AIM

To confirm or reject the hypothesis of a bimodal distribution of depressive symptoms.

METHODS

A sample of 1,159 randomly selected nursing home patients was assessed using the Cornell Scale, the Clinical Dementia Rating Scale (CDR) and Lawton's Scale of the activities of daily living. Additionally, information was collected from the patients' records. A factor analysis of the Cornell Scale was performed.

RESULTS

The use of antidepressants and demographic characteristics, except for gender distribution, did not differ across CDR groups. Patients with dementia had more symptoms such as anxiety, irritability, agitation, retardation, loss of interest, lack of joy and delusion than those without dementia. No symptom was more frequent among non-demented subjects. The factor analysis resulted in a five factors solution: 'mood', 'cyclic', 'physical', 'retardation' and 'behavioural' factor. The score on the mood subscale did not differ across CDR groups (p = 0.326), whereas the scores on the four other subscales increased with increasing CDR scores (p < 0.001).

CONCLUSION

We did not find a bimodal distribution of depressive symptoms. The explanation for the occurrence of the typical core symptoms of depression, the mood symptoms, is probably complex. The non-mood symptoms are probably strongly influenced by biological factors.

摘要

背景

痴呆患者中抑郁症的患病率高于非痴呆患者。由于心理和生物学风险因素,有人提出抑郁症状呈双峰分布,在轻度和重度痴呆患者中患病率较高。

目的

证实或否定抑郁症状双峰分布的假设。

方法

使用康奈尔量表、临床痴呆评定量表(CDR)和劳顿日常生活活动量表对1159名随机选择的养老院患者进行评估。此外,还从患者记录中收集信息。对康奈尔量表进行因子分析。

结果

除性别分布外,抗抑郁药的使用和人口统计学特征在CDR组之间没有差异。痴呆患者比非痴呆患者有更多的症状,如焦虑、易怒、激动、迟缓、兴趣丧失、缺乏快乐和妄想。没有症状在非痴呆受试者中更常见。因子分析得出了一个五因素解决方案:“情绪”、“周期性”、“身体”、“迟缓”和“行为”因子。情绪子量表的得分在CDR组之间没有差异(p = 0.326),而其他四个子量表的得分随着CDR得分的增加而增加(p < 0.001)。

结论

我们没有发现抑郁症状的双峰分布。抑郁典型核心症状即情绪症状出现的原因可能很复杂。非情绪症状可能受生物学因素的强烈影响。

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