Syme Catriona, Abrahamowicz Michal, Leonard Gabriel T, Perron Michel, Pitiot Alain, Qiu Xi, Richer Louis, Totman John, Veillette Suzanne, Xiao Yongling, Gaudet Daniel, Paus Tomas, Pausova Zdenka
Brain and Body Centre, University of Nottingham, Nottingham, England.
Arch Pediatr Adolesc Med. 2008 May;162(5):453-61. doi: 10.1001/archpedi.162.5.453.
To investigate the association between intra-abdominal adiposity and individual components of the metabolic syndrome (MS) in adolescent males and females.
Cross-sectional study of a population-based cohort.
Saguenay Youth Study, Quebec, Canada.
A total of 324 adolescents, aged 12 to 18 years.
Measures were compared between males and females with "high" or "low" intra-abdominal fat (IAF).
Intra-abdominal fat was quantified with magnetic resonance imaging. Primary outcome measures were blood pressure (BP) and fasting serum glucose, insulin, lipids, and C-reactive protein levels. Secondary mechanistic measures were cardiovascular variability indexes of autonomic nervous system function, pubertal development, and serum levels of cortisol, leptin, and sex hormones.
The MS was completely absent in adolescents with low IAF and was present in 13.8% of males and 8.3% of females with high IAF. Excess IAF was associated with a higher homeostasis model assessment index (0.5 [95% confidence interval (CI), 0.3 to 0.8]; P < .001) and triglycerides level (17.7 mg/dL [to convert to millimoles per liter, multiply by 0.0113] [95% CI, 9.7 to 25.7 mg/dL]; P < .001), lower high-density lipoprotein cholesterol level (-3.9 mg/dL [to convert to millimoles per liter, multiply by 0.0259] [95% CI, -6.2 to -1.5 mg/dL]; P = .003), and higher C-reactive protein level (0.03 mg/L [to convert to nanomoles per liter, multiply by 9.524] [95% CI, 0.01 to 0.05 mg/L]; P = .003). High IAF was associated with elevations of BP and sympathetic activity in males only (higher systolic BP, 6 mm Hg [95% CI, 1 to 11 mm Hg]; P = .02 and low-frequency power of diastolic BP, 629 mm Hg2 [95% CI, 37 to 1222 mm Hg2]; P = .04).
Our results suggest that, already in adolescence, accumulation of IAF may promote development of the MS, affecting the metabolic and inflammatory components similarly in both sexes but influencing BP adversely only in males. The latter may be attributed, in part, to the augmentation of sympathetic activity also seen only in males.
研究青春期男性和女性腹内脂肪过多与代谢综合征（MS）各单项组分之间的关联。
基于人群队列的横断面研究。
加拿大魁北克省萨格奈青年研究。
共324名12至18岁的青少年。
比较腹内脂肪（IAF）“高”或“低”的男性和女性之间的各项测量指标。
采用磁共振成像对腹内脂肪进行量化。主要观察指标为血压（BP）、空腹血清葡萄糖、胰岛素、血脂和C反应蛋白水平。次要机制性指标为自主神经系统功能的心血管变异性指数、青春期发育情况以及皮质醇、瘦素和性激素的血清水平。
IAF低的青少年中完全不存在MS，而IAF高的青少年中，男性有13.8%、女性有8.3%存在MS。IAF过多与更高的稳态模型评估指数（0.5 [95%置信区间（CI），0.3至0.8]；P <.001）和甘油三酯水平（17.7 mg/dL [换算为毫摩尔每升，乘以0.0113] [95% CI，9.7至25.7 mg/dL]；P <.001）、更低的高密度脂蛋白胆固醇水平（-3.9 mg/dL [换算为毫摩尔每升，乘以0.0259] [95% CI，-6.2至-1.5 mg/dL]；P = 0.003）以及更高的C反应蛋白水平（0.03 mg/L [换算为纳摩尔每升，乘以9.524] [95% CI，0.01至0.05 mg/L]；P = 0.003）相关。高IAF仅与男性的血压升高和交感神经活动增强有关（收缩压更高，6 mmHg [95% CI，1至11 mmHg]；P = 0.02；舒张压的低频功率，629 mmHg² [95% CI，37至1222 mmHg²]；P = 0.04）。
我们的结果表明，在青春期，IAF的积累可能就会促进MS的发展，对两性的代谢和炎症组分产生相似影响，但仅对男性的血压产生不利影响。后者可能部分归因于仅在男性中也出现的交感神经活动增强。
