不同狭义伯氏疏螺旋体基因型导致人类播散性感染的倾向。
The propensity of different Borrelia burgdorferi sensu stricto genotypes to cause disseminated infections in humans.
作者信息
Dykhuizen Daniel E, Brisson Dustin, Sandigursky Sabina, Wormser Gary P, Nowakowski John, Nadelman Robert B, Schwartz Ira
机构信息
Department of Ecology and Evolution, Stony Brook University, Stony Brook, New York 11794, USA.
出版信息
Am J Trop Med Hyg. 2008 May;78(5):806-10.
Abstract
Lineages of Borrelia burgdorferi, the bacterium that causes Lyme disease, can be characterized by distinct alleles at the outer surface protein C (ospC) locus. The lineages marked by ospC genotypes have been shown to be differentially invasive in different species of mammals, including humans; genotypes A, B, I, and K effectively disseminate to human blood and cerebrospinal fluid. In this report, we extend the sample of genotypes isolated from human blood to include genotypes N, H, C, M, and D, and rank each by their probability of disseminating from ticks to the blood of humans. Our results demonstrate that only some genotypes of B. burgdorferi present in ticks have a high propensity to disseminate in humans.
摘要
引起莱姆病的伯氏疏螺旋体的菌系可以通过外表面蛋白C（ospC）位点的不同等位基因来表征。已证明由ospC基因型标记的菌系在包括人类在内的不同哺乳动物物种中具有不同的侵袭性；基因型A、B、I和K能有效地传播到人体血液和脑脊液中。在本报告中，我们扩大了从人体血液中分离出的基因型样本，纳入了基因型N、H、C、M和D，并根据它们从蜱传播到人体血液的可能性对每种基因型进行排名。我们的结果表明，蜱体内存在的伯氏疏螺旋体只有某些基因型在人类中有很高的传播倾向。
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Genetic diversity of Borrelia burgdorferi sensu stricto in Peromyscus leucopus, the primary reservoir of Lyme disease in a region of endemicity in southern Maryland.马里兰州南部莱姆病流行区主要宿主白足鼠体内狭义伯氏疏螺旋体的遗传多样性
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