纳米多孔二氧化钛薄膜的药物负载

Drug loading of nanoporous TiO2 films.

作者信息

Ayon Arturo A, Cantu Michael, Chava Kalpana, Agrawal C Mauli, Feldman Marc D, Johnson Dave, Patel Devang, Marton Denes, Shi Emily

机构信息

MEMS Research Laboratory, Department of Electrical and Computer Engineering, University of Texas at San Antonio, San Antonio, TX, USA.

出版信息

Biomed Mater. 2006 Dec;1(4):L11-5. doi: 10.1088/1748-6041/1/4/L01. Epub 2006 Aug 25.

DOI:10.1088/1748-6041/1/4/L01

PMID:18458401

Abstract

The loading of therapeutic amounts of drug on a nanoporous TiO(2) surface is described. This novel drug-loading scheme on a biocompatible surface, when employed on medical implants, will benefit patients who require the deployment of drug-eluting implants. Anticoagulants, analgesics and antibiotics can be considered on the associated implants for drug delivery during the time of maximal pain or risk for patients undergoing orthopedic procedures. Therefore, this scheme will maximize the chances of patient recovery.

摘要

描述了在纳米多孔TiO(2)表面负载治疗剂量的药物。这种在生物相容性表面上的新型药物负载方案，应用于医疗植入物时，将使需要使用药物洗脱植入物的患者受益。对于接受骨科手术的患者，在疼痛最剧烈或风险最大时，相关植入物上可考虑使用抗凝血剂、止痛剂和抗生素进行药物递送。因此，该方案将最大限度地提高患者康复的机会。