Electronic Materials Research Institute, Northeastern University, Boston, MA 02115, USA.
Adv Drug Deliv Rev. 2010 Mar 8;62(3):305-15. doi: 10.1016/j.addr.2009.11.003. Epub 2009 Nov 14.
The characteristics of nanoporous inorganic coatings on implants or on implantable devices are reviewed. The commonly used nanoporous materials, such as aluminum oxide (Al(2)O(3)), titanium oxide (TiO(2)) and porous silicon are highlighted with illustrative examples. The critical issues for sustained release systems are examined and the elution profiles of nanoporous coatings are discussed. The available data shows that these systems can be used effectively for sustained release applications. They satisfy the basic biocompatibility tests, meet the requirements of drug loading and sustained release profiles extending to several weeks and also are compatible with current implant technologies. Nanoporous inorganic coatings are well suited to provide improved efficacy and integration of implants in a variety of therapeutic situations.
对植入物或可植入装置上的纳米多孔无机涂层的特性进行了综述。文中突出了一些常用的纳米多孔材料，如氧化铝（Al(2)O(3)）、二氧化钛（TiO(2)) 和多孔硅，并列举了说明性实例。还对缓释系统的关键问题进行了研究，并讨论了纳米多孔涂层的洗脱曲线。现有数据表明，这些系统可有效地用于缓释应用。它们满足基本的生物相容性测试，满足药物负载和可持续释放曲线延长至数周的要求，并且与当前的植入技术兼容。纳米多孔无机涂层非常适合在各种治疗情况下提高植入物的疗效和整合性。
