纳米医学在心血管疾病诊断和治疗中的新兴应用。
Emerging applications of nanomedicine for the diagnosis and treatment of cardiovascular diseases.
机构信息
Department of NanoMedicine and Biomedical Engineering, The University of Texas Health Science Center at Houston,1825 Pressler, Suite 537, Houston, TX 77030, USA.
出版信息
Trends Pharmacol Sci. 2010 May;31(5):199-205. doi: 10.1016/j.tips.2010.01.003. Epub 2010 Feb 19.
Abstract
Nanomedicine is an emerging field that utilizes nanotechnology concepts for advanced therapy and diagnostics. This convergent discipline merges research areas such as chemistry, biology, physics, mathematics and engineering. It therefore bridges the gap between molecular and cellular interactions, and has the potential to revolutionize medicine. This review presents recent developments in nanomedicine research poised to have an important impact on the treatment of cardiovascular disease. This will occur through improvement of the diagnosis and therapy of cardiovascular disorders as atherosclerosis, restenosis and myocardial infarction. Specifically, we discuss the use of nanoparticles for molecular imaging and advanced therapeutics, specially designed drug eluting stents and in vivo/ex vivo early detection techniques.
摘要
纳米医学是一个新兴的领域，利用纳米技术概念进行先进的治疗和诊断。这一融合学科融合了化学、生物学、物理学、数学和工程学等研究领域。因此，它弥合了分子和细胞相互作用之间的差距，并有可能彻底改变医学。本综述介绍了纳米医学研究的最新进展，这些进展有可能对心血管疾病的治疗产生重要影响。这将通过改善动脉粥样硬化、再狭窄和心肌梗死等心血管疾病的诊断和治疗来实现。具体而言，我们讨论了使用纳米粒子进行分子成像和先进治疗，特别是设计用于药物洗脱支架和体内/体外早期检测技术的纳米粒子。
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