Ducatez M F, Chen H, Guan Y, Muller C P
Institute of Immunology, Laboratoire National de Santé, 20A, rue Auguste Lumière, L-1950 Luxembourg, Grand-Duchy of Luxembourg.
Avian Dis. 2008 Mar;52(1):68-73. doi: 10.1637/8049-070407-Reg.
Between January 2004 and December 2005, cloacal swabs from essentially healthy chickens and silky chickens from live birds markets in Guangdong and Hunan provinces in southeastern China were screened for chicken anemia virus (CAV) by polymerase chain reaction. Phylogenetic analysis of the major structural protein VP1 sequences showed no clear genotype cluster and no correlation with the geographic origin of CAV strains. Virus evolution at the amino acid level was very slow, which corresponds to a strong negative selection of the VP1 gene in China and worldwide. A high proportion (87%) of birds was CAV positive, suggesting that many farms in the region were infected. Further investigations are necessary to evaluate the economic losses caused by CAV and the cost-benefit of vaccination.
2004年1月至2005年12月期间，采用聚合酶链反应对中国东南部广东省和湖南省活禽市场上基本健康的鸡和丝毛鸡的泄殖腔拭子进行鸡贫血病毒（CAV）筛查。对主要结构蛋白VP1序列进行系统发育分析，结果显示没有明显的基因型聚类，且与CAV毒株的地理起源无关。在氨基酸水平上，病毒进化非常缓慢，这与中国和全球范围内VP1基因的强烈负选择相一致。高比例（87%）的禽类CAV呈阳性，表明该地区许多养殖场已被感染。有必要进一步开展调查，以评估CAV造成的经济损失以及疫苗接种的成本效益。
