Valentim Ana M, Alves Heber C, Olsson I Anna S, Antunes Luís M
Laboratory Animal Science, Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.
J Am Assoc Lab Anim Sci. 2008 May;47(3):16-9.
Studies on humans and rodents indicate possible long-term cognitive impairment after surgery or general anesthesia. The goal of this study was to evaluate the effect of various anesthetic concentrations on spatial learning in adult mice. The behavior of adult mice in a T-maze was assessed 28 h after anesthesia (control [0%], low [1%], or high [2%] isoflurane concentration). The mice anesthetized with 1% isoflurane had a significantly poorer performance than did the other 2 groups. The performance of the mice anesthetized with 2% isoflurane was not statistically different from that of the control group. Therefore, low, not high, isoflurane concentration impaired spatial learning in mice.
对人类和啮齿动物的研究表明，手术或全身麻醉后可能会出现长期认知障碍。本研究的目的是评估不同麻醉浓度对成年小鼠空间学习的影响。在麻醉后28小时（对照组[0%]、低浓度组[1%]或高浓度组[2%]异氟烷浓度）评估成年小鼠在T迷宫中的行为。用1%异氟烷麻醉的小鼠表现明显比其他两组差。用2%异氟烷麻醉的小鼠表现与对照组无统计学差异。因此，是低浓度而非高浓度的异氟烷损害了小鼠的空间学习能力。
