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巴西南部与牛疱疹病毒感染相关的牛神经系统疾病。

Neurological disease in cattle in southern Brazil associated with Bovine herpesvirus infection.

作者信息

Rissi Daniel Ricardo, Pierezan Felipe, Sá e Silva Mariana, Flores Eduardo Furtado, de Barros Claudio Severo Lombardo

机构信息

Departament of Pathology, Laboratory of Veterinary Pathology, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.

出版信息

J Vet Diagn Invest. 2008 May;20(3):346-9. doi: 10.1177/104063870802000315.

Abstract

The occurrence of neurological disease in cattle caused by Bovine herpesvirus in 11 farms from southern Brazil between 1987 and 2007 is described. Twenty-two animals were necropsied. Major clinical signs included excessive salivation, nasal and ocular discharge, circling, recumbency, depression, incoordination, grinding of teeth, and paddling movements. Necropsy findings in 10 of 22 cattle included hyperemia and softening of the rostral portions of the telencephalic cortex, with flattening of gyri, and malacia. Cattle in 10 cases did not show any gross lesions. Histological examination in most cases revealed nonsuppurative and necrotizing meningoencephalitis with acute neuronal necrosis, edema, eosinophilic intranuclear inclusion bodies in astrocytes and neurons, and infiltration of gitter cells. No histologic lesions could be detected in 4 cases. The initial diagnosis was based upon the clinical, epidemiological, and pathological findings. The diagnosis was confirmed by virus isolation in cell culture followed by virus identification by a glycoprotein C-based polymerase chain reaction. Seven isolates were identified as Bovine herpesvirus 5, and 4 were identified as Bovine herpesvirus 1.

摘要

描述了1987年至2007年间巴西南部11个农场中由牛疱疹病毒引起的牛神经疾病的发生情况。对22头动物进行了尸检。主要临床症状包括流涎过多、鼻眼分泌物增多、转圈、侧卧、抑郁、共济失调、磨牙和划水动作。22头牛中有10头的尸检结果包括端脑皮质前部充血和软化,脑回变平,以及软化。10例牛未显示任何肉眼可见的病变。大多数病例的组织学检查显示非化脓性坏死性脑膜脑炎,伴有急性神经元坏死、水肿、星形胶质细胞和神经元中的嗜酸性核内包涵体,以及格子细胞浸润。4例未检测到组织学病变。初步诊断基于临床、流行病学和病理学发现。通过细胞培养中的病毒分离,随后通过基于糖蛋白C的聚合酶链反应进行病毒鉴定,确诊了诊断。7株分离株被鉴定为牛疱疹病毒5型,4株被鉴定为牛疱疹病毒1型。

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