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本文引用的文献

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Animal models and vaccines for SARS-CoV infection.用于严重急性呼吸综合征冠状病毒（SARS-CoV）感染的动物模型和疫苗。
Virus Res. 2008 Apr;133(1):20-32. doi: 10.1016/j.virusres.2007.03.025. Epub 2007 May 11.
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Vaccines to prevent severe acute respiratory syndrome coronavirus-induced disease.预防严重急性呼吸综合征冠状病毒所致疾病的疫苗。
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Vaccine efficacy in senescent mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variants.用携带流行和人畜共患刺突变体的重组SARS-CoV攻击衰老小鼠后的疫苗效力。
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A severe acute respiratory syndrome coronavirus that lacks the E gene is attenuated in vitro and in vivo.一种缺乏E基因的严重急性呼吸综合征冠状病毒在体外和体内均表现出减毒特性。
J Virol. 2007 Feb;81(4):1701-13. doi: 10.1128/JVI.01467-06. Epub 2006 Nov 15.
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Construction of a severe acute respiratory syndrome coronavirus infectious cDNA clone and a replicon to study coronavirus RNA synthesis.构建严重急性呼吸综合征冠状病毒感染性cDNA克隆和复制子以研究冠状病毒RNA合成。
J Virol. 2006 Nov;80(21):10900-6. doi: 10.1128/JVI.00385-06. Epub 2006 Aug 23.
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Bats are natural reservoirs of SARS-like coronaviruses.蝙蝠是类严重急性呼吸综合征冠状病毒的天然宿主。
Science. 2005 Oct 28;310(5748):676-9. doi: 10.1126/science.1118391. Epub 2005 Sep 29.
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Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats.中华菊头蝠体内的严重急性呼吸综合征样冠状病毒
Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14040-5. doi: 10.1073/pnas.0506735102. Epub 2005 Sep 16.
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Severe acute respiratory syndrome coronavirus infection of golden Syrian hamsters.叙利亚金黄地鼠的严重急性呼吸综合征冠状病毒感染
J Virol. 2005 Jan;79(1):503-11. doi: 10.1128/JVI.79.1.503-511.2005.
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An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus.一种从记忆B细胞制备人单克隆抗体的有效方法：对严重急性呼吸综合征冠状病毒的有效中和作用
Nat Med. 2004 Aug;10(8):871-5. doi: 10.1038/nm1080. Epub 2004 Jul 11.
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Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of mice.先前感染和中和抗体的被动转移可预防严重急性呼吸综合征冠状病毒在小鼠呼吸道中的复制。
J Virol. 2004 Apr;78(7):3572-7. doi: 10.1128/jvi.78.7.3572-3577.2004.

一种减毒活严重急性呼吸综合征冠状病毒在叙利亚金黄地鼠中具有免疫原性且有效。

A live attenuated severe acute respiratory syndrome coronavirus is immunogenic and efficacious in golden Syrian hamsters.

作者信息

Lamirande Elaine W, DeDiego Marta L, Roberts Anjeanette, Jackson Jadon P, Alvarez Enrique, Sheahan Tim, Shieh Wun-Ju, Zaki Sherif R, Baric Ralph, Enjuanes Luis, Subbarao Kanta

机构信息

Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892, USA.

出版信息

J Virol. 2008 Aug;82(15):7721-4. doi: 10.1128/JVI.00304-08. Epub 2008 May 7.

DOI:10.1128/JVI.00304-08
PMID:18463152
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2493341/
Abstract

The immunogenicity and protective efficacy of a live attenuated vaccine consisting of a recombinant severe acute respiratory syndrome (SARS) coronavirus lacking the E gene (rSARS-CoV-DeltaE) were studied using hamsters. Hamsters immunized with rSARS-CoV-DeltaE developed high serum-neutralizing antibody titers and were protected from replication of homologous (SARS-CoV Urbani) and heterologous (GD03) SARS-CoV in the upper and lower respiratory tract. rSARS-CoV-DeltaE-immunized hamsters remained active following wild-type virus challenge, while mock-immunized hamsters displayed decreased activity. Despite being attenuated in replication in the respiratory tract, rSARS-CoV-DeltaE is an immunogenic and efficacious vaccine in hamsters.

摘要

利用仓鼠研究了一种缺失E基因的重组严重急性呼吸综合征（SARS）冠状病毒减毒活疫苗（rSARS-CoV-DeltaE）的免疫原性和保护效力。用rSARS-CoV-DeltaE免疫的仓鼠产生了高血清中和抗体滴度，并在上、下呼吸道免受同源（SARS-CoV Urbani）和异源（GD03）SARS-CoV的复制。rSARS-CoV-DeltaE免疫的仓鼠在受到野生型病毒攻击后仍保持活跃，而模拟免疫的仓鼠活动减少。尽管rSARS-CoV-DeltaE在呼吸道中的复制能力减弱，但它在仓鼠中是一种具有免疫原性且有效的疫苗。