Otsuki Takeshi, Maeda Seiji, Iemitsu Motoyuki, Saito Yoko, Tanimura Yuko, Ajisaka Ryuichi, Miyauchi Takashi
Health and Sports Management Major, Faculty of Health and Welfare Human Services, St. Catherine University, Matsuyama, Ehime, Japan.
Am J Physiol Regul Integr Comp Physiol. 2008 Jul;295(1):R228-35. doi: 10.1152/ajpregu.00009.2008. Epub 2008 May 7.
Systemic arterial compliance (C) and vascular resistance (R) regulate effective arterial elastance (Ea), an index of artery load. Increases in Ea during exercise are due primarily to reductions of C and maintain optimal ventricular-arterial coupling. Because C at rest and left ventricular functional reserve are greater in endurance-trained (ET) compared with sedentary control (SC) humans, we hypothesized that reductions of C and increases in Ea are greater in ET than SC individuals. The aim of this study was to investigate C, R, and Ea during exercise in ET and SC humans. C, R, Ea, and cardiac cycle length (T) were measured at rest and during exercise of 40, 60, and 80% maximal oxygen uptake using Doppler ultrasonography in 12 SC and 13 ET men. C decreased in an exercise intensity-dependent manner in both groups, but its reductions were greater in the ET than SC subjects. Consequently, although C at rest was greater in the ET than SC group, the intergroup difference in C disappeared during exercise. Exercise-related changes in R/T were relatively slight and R/T was lower in the ET than the SC group, both at rest and during exercise. Although Ea at rest was lower in the ET than SC group, there were no intergroup differences in Ea at 40, 60, or 80% maximal oxygen uptake. We conclude that the reductions of C from rest to exercise are more marked in ET than SC humans. This may be related to the exercise-associated disappearance of the difference in Ea between ET and SC humans.
全身动脉顺应性（C）和血管阻力（R）调节有效动脉弹性（Ea），这是一个反映动脉负荷的指标。运动期间Ea的增加主要归因于C的降低，并维持最佳的心室 - 动脉耦合。由于与久坐不动的对照（SC）人群相比，耐力训练（ET）人群在静息时的C和左心室功能储备更大，我们推测ET个体中C的降低和Ea的增加比SC个体更显著。本研究的目的是调查ET和SC人群运动期间的C、R和Ea。使用多普勒超声在12名SC男性和13名ET男性静息时以及在最大摄氧量的40%、60%和80%的运动期间测量C、R、Ea和心动周期长度（T）。两组中C均以运动强度依赖的方式降低，但ET组中C的降低幅度大于SC组。因此，尽管ET组静息时的C高于SC组，但运动期间两组间C的差异消失。R/T与运动相关的变化相对较小，并且在静息和运动期间，ET组的R/T均低于SC组。尽管ET组静息时的Ea低于SC组，但在最大摄氧量的40%、60%或80%时，两组间Ea没有差异。我们得出结论，从静息到运动时C的降低在ET人群中比SC人群更明显。这可能与ET和SC人群之间运动相关的Ea差异消失有关。
